ArticleMolecular and cellular biology1997
Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 87 citations in OpenAlex.
- Weak membrane interactions allow Rheb to activate mTORC1 signaling without major lysosome enrichment.Molecular biology of the cell · 2019Article
- An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation.BMC cancer · 2018Article
- mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation.The Journal of clinical investigation · 2015Article
- Insight into the role of mTOR and metabolism in T cells reveals new potential approaches to preventing graft rejection.Current opinion in organ transplantation · 2014Review
- Regulation of TOR by small GTPases.EMBO reports · 2012Review
- Regulation of immune responses by mTOR.Annual review of immunology · 2012Review
- Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR: involvement of C/EBPβ and mTOR-dependent dephosphorylation of Akt.Molecular and cellular biology · 2011Article
- The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.Nature immunology · 2011Article
- Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis.EMBO molecular medicine · 2011Review
- Raf family kinases: old dogs have learned new tricks.Genes & cancer · 2011Article
- The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism.Immunity · 2010Review
- Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia.Blood · 2010Article
- Rheb G-Proteins and the Activation of mTORC1.The Enzymes · 2010Article
- The function of activity-regulated genes in the nervous system.Physiological reviews · 2009Review
- Constitutively active Rheb induces oncogenic transformation.Oncogene · 2008Article
- Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B.Molecular biology reports · 2005Article
- Signaling by target of rapamycin proteins in cell growth control.Microbiology and molecular biology reviews : MMBR · 2005Review
- Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.Genes & development · 2003Article
- Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of Invasive pulmonary aspergillosis.Infection and immunity · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Rheb is a recently described member of the Ras family that was originally identified as an immediate-early gene in brain but is also widely expressed in other tissues. Here we demonstrate that Rheb interacts with and appears to regulate Raf-1 kinase, an essential component of the H-Ras signaling pathway. In direct contrast to H-Ras, however, the interaction of Rheb with Raf-1 is potentiated by growth factors in combination with agents that increase cyclic AMP (cAMP) levels. Protein kinase A-dependent phosphorylation of serine 43 within the regulatory domain of Raf-1 reciprocally potentiates its interaction with Rheb and decreases its interaction with H-Ras. A single amino acid in the G2 effector domain is critical for the differential properties of Rheb. Since Rheb is an immediate-early gene, our studies suggest that Rheb functions in concert with H-Ras to dynamically integrate cAMP and growth factor signaling.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.