Trial reportThe Journal of clinical investigation1997
The vascular effects of L-Arginine in humans. The role of endogenous insulin.
Trial report in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Impact of Amino Acids on Postprandial Glucose and Insulin Kinetics in Humans: A Quantitative Overview.Nutrients · 2020Pooled it
- Acute L-arginine supplementation has no effect on cardiovascular or thermoregulatory responses to rest, exercise, and recovery in the heat.European journal of applied physiology · 2016Trial
- Muscle glycogen recovery after exercise measured by 13C-magnetic resonance spectroscopy in humans: effect of nutritional solutions.Magma (New York, N.Y.) · 2000Trial
- Effects of L-arginine on lower limb vasodilator reserve and exercise capacity in patients with chronic heart failure.Heart (British Cardiac Society) · 1999Trial
- L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship.British journal of clinical pharmacology · 1998Trial
- Exogenous L-arginine does not affect angiotensin II-induced renal vasoconstriction in man.British journal of clinical pharmacology · 1998Trial
- Identifying serum amino acid as biomarkers of gestational diabetes mellitus in second-trimester among Chinese pregnant women: a machine learning-based cross-sectional study.Reproductive health · 2026Article
- Article
- The effects of citrulline supplementation on meta-inflammation and insulin sensitivity in type 2 diabetes: a randomized, double-blind, placebo-controlled trial.Diabetology & metabolic syndrome · 2021Article
- Arginine and Endothelial Function.Biomedicines · 2020Review
- Serum nitric oxide levels in healthy pregnant women: a case- control study in a tertiary facility in Ghana.Maternal health, neonatology and perinatology · 2018Article
- Hormonal response to L-arginine supplementation in physically active individuals.Food & nutrition research · 2014Article
- Impact of postprandial glycaemia on health and prevention of disease.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2012Review
- Comparison of pre-workout nitric oxide stimulating dietary supplements on skeletal muscle oxygen saturation, blood nitrate/nitrite, lipid peroxidation, and upper body exercise performance in resistance trained men.Journal of the International Society of Sports Nutrition · 2010Article
- Effect of oral acetyl L-carnitine arginate on resting and postprandial blood biomarkers in pre-diabetics.Nutrition & metabolism · 2009Article
- Article
- Interaction of the endothelial nitric oxide synthase with the CAT-1 arginine transporter enhances NO release by a mechanism not involving arginine transport.The Biochemical journal · 2005Article
- Effects of L-arginine on flow mediated dilatation induced by atrial pacing in diseased epicardial coronary arteries.Heart (British Cardiac Society) · 2003Article
- Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Acute and chronic endothelial dysfunction: implications for the development of heart failure.Heart failure reviews · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed at evaluating whether increased availability of the natural precursor of nitric oxide, L-arginine, could influence systemic hemodynamic and rheologic parameters in humans and whether the effects of L-arginine are mediated by endogenous insulin. 10 healthy young subjects participated in the following studies: study I, infusion of L-arginine (1 g/min for 30 min); study II, infusion of L-arginine plus octreotide (25 microg as i.v. bolus + 0.5 microg/min) to block endogenous insulin and glucagon secretion, plus replacement of basal insulin and glucagon; study III, infusion of L-arginine plus octreotide plus basal glucagon plus an insulin infusion designed to mimic the insulin response of study I. L-Arginine infusion significantly reduced systolic (11+/-3, mean+/-SE) and diastolic (8+/-2 mmHg, P < 0.001) blood pressure, platelet aggregation (20+/-4%), and blood viscosity (1.6+/-0.2 centipois, P < 0.01), and increased leg blood flow (97+/-16 ml/min), heart rate, and plasma catecholamine levels (P < 0.01). In study II, plasma insulin levels remained suppressed at baseline; in this condition, the vascular responses to L-arginine were significantly reduced, except for plasma catecholamines which did not change significantly. In study III, the plasma insulin response to L-arginine was reestablished; this was associated with hemodynamic and rheologic changes following L-arginine not significantly different from those recorded in study I. These findings show that systemic infusion of L-arginine in healthy subjects induces vasodilation and inhibits platelet aggregation and blood viscosity. These effects are mediated, in part, by endogenous released insulin.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.