ArticleNeurology1997
Clinical dementia rating training and reliability in multicenter studies: the Alzheimer's Disease Cooperative Study experience.
Article in Neurology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 192 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combination of Intranasal Insulin With Oral Semaglutide to Improve Cognition and Cerebral Blood Flow: a Feasibility Study
Device Study for Intranasal Delivery of Insulin
SNIFF Multi-Device Study 2 - Study of Nasal Insulin to Fight Forgetfulness
Study of Nasal Insulin to Fight Forgetfulness (SNIFF) - 3-Week Aptar CPS Device
Study of Nasal Insulin to Fight Forgetfulness - Combination Intranasal Insulin and Empagliflozin Trial
Who cites it
192 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tele-neuropsychological assessment tools in Italy: a systematic review on psychometric properties and usability.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Baseline cognition and demographic, lifestyle, and cardiovascular risk factors in US POINTER.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Tau-targeting antisense oligonucleotide MAPTNature medicine · 2023Trial
- Does computerized cognitive training improve diabetes self-management and cognition? A randomized control trial of middle-aged and older veterans with type 2 diabetes.Diabetes research and clinical practice · 2023Trial
- Trial
- Promoting activity, Independence and stability in early dementia (PrAISED): a, multisite, randomised controlled, feasibility trial.BMC geriatrics · 2019Trial
- Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer's Disease: Results of the DIAN Study.BioMed research international · 2015Trial
- Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Cortical neuroanatomic correlates of symptom severity in primary progressive aphasia.Neurology · 2010Trial
- A randomized placebo-controlled trial of Ginkgo biloba for the prevention of cognitive decline.Neurology · 2008Trial
- Different family caregiver- and care recipient-related factors are associated with the cost of care in the early, mild, and moderate stages of Alzheimer's disease in Finland: A 5-year ALSOVA study.The European journal of health economics : HEPAC : health economics in prevention and care · 2026Article
- Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Predictors of long-term care admission in a rural and remote memory clinic.Journal of Alzheimer's disease : JAD · 2026Article
- Frequent in dementia, deadliest without it: delirium and mortality in hospitalised older adults.Age and ageing · 2026Article
- Neural embedding of frailty in cognitively unimpaired aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Bidirectional prognostic predictions of conversion and reversion in amnestic mild cognitive impairment.GeroScience · 2026Article
- Standardizing "Rapid": Applying the Clinical Dementia Rating to Define Rapidly Progressive Dementia.Neurology · 2026Article
- Observational
- Gait speed as a superior screening indicator for mild cognitive impairment compared to walk ratio and dual-task cost: a cross-sectional study.European geriatric medicine · 2025Article
- Alzheimer's disease transcriptional landscape in ex vivo human microglia.Nature neuroscience · 2025Article
132 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Global ratings of dementia severity are used increasingly in clinical trials of antidementia compounds. Such ratings are clinically relevant, but their reliability in multicenter settings has not been determined. To evaluate the reliability of one global scale, the Clinical Dementia Rating (CDR), 82 investigators of the multicenter Alzheimer's Disease Cooperative Study participated in a training and reliability protocol using videotaped assessments of subjects in various stages of Alzheimer's disease. Following training, overall agreement of the investigators with "gold standard" CDR scores was 83%. These results indicate that the training protocol is useful for establishing good levels of agreement in staging dementia severity and that the CDR can be standardized as a clinical global scale for multicenter studies of Alzheimer's disease.
Indexed as
Identifiers
9191756What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.