ArticleProceedings of the National Academy of Sciences of the United States of America1997
The beta subunit of CKII negatively regulates Xenopus oocyte maturation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Re-evaluation of protein kinase CK2 pleiotropy: new insights provided by a phosphoproteomics analysis of CK2 knockout cells.Cellular and molecular life sciences : CMLS · 2018Article
- Inhibition of casein kinase 2 blocks GThe Journal of reproduction and development · 2017Article
- Adiponectin receptor 1 interacts with both subunits of protein kinase CK2.Molecular and cellular biochemistry · 2011Article
- Enforcing temporal control of maternal mRNA translation during oocyte cell-cycle progression.The EMBO journal · 2010Article
- FW2.2 and cell cycle control in developing tomato fruit: a possible example of gene co-option in the evolution of a novel organ.Plant molecular biology · 2006Article
- Mechanistic studies of the mitotic activation of Mos.Molecular and cellular biology · 2006Article
- CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolism.Molecular and cellular biology · 2004Article
- Restricted specificity of Xenopus TFIIIA for transcription of somatic 5S rRNA genes.Molecular and cellular biology · 2004Article
- Design of genetic networks with specified functions by evolution in silico.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Live-cell fluorescence imaging reveals the dynamics of protein kinase CK2 individual subunits.Molecular and cellular biology · 2003Article
- Protein kinase CK2: structure, regulation and role in cellular decisions of life and death.The Biochemical journal · 2003Review
- A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation.The EMBO journal · 2002Article
- Identification of protein tyrosine phosphatase 1B and casein as substrates for 124-v-Mos.BMC biochemistry · 2002Article
- Two distinct mechanisms control the accumulation of cyclin B1 and Mos in Xenopus oocytes in response to progesterone.Molecular biology of the cell · 1999Article
- p70(S6K) controls selective mRNA translation during oocyte maturation and early embryogenesis in Xenopus laevis.Molecular and cellular biology · 1999Article
- Expression and regulation of protein kinase CK2 during the cell cycle.Molecular and cellular biochemistry · 1999Article
- The kinase Eg2 is a component of the Xenopus oocyte progesterone-activated signaling pathway.The EMBO journal · 1998Article
- Protein kinase CK2 interacts with and phosphorylates the Arabidopsis circadian clock-associated 1 protein.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
CKII (formerly known as casein kinase II) is a ubiquitously expressed enzyme that plays an important role in regulating cell growth and differentiation. The beta subunit of CKII (CKIIbeta) is not catalytic but forms heterotetramers with the catalytic subunit alpha to generate an alpha2beta2 holoenzyme. In Xenopus oocytes, CKIIbeta also associates with another serine/threonine kinase, Mos. As a key regulator of meiosis, Mos is necessary and sufficient to initiate oocyte maturation. We have previously shown that the binding of CKIIbeta to Mos represses Mos-mediated mitogen-activated protein kinase (MAPK) activation and that the ectopic expression of CKIIbeta inhibits progesterone-induced Xenopus oocyte maturation. We have now used an antisense oligonucleotide technique to reduce the endogenous CKIIbeta protein level in Xenopus oocytes, and we find that oocytes with a reduced content of CKIIbeta are more sensitive to low doses of progesterone and show accelerated MAPK activation and germinal vesicle breakdown. Furthermore, ectopic expression of a Mos-binding fragment of CKIIbeta suppressed the effect of antisense oligonucleotide. These results suggest that the endogenous CKIIbeta normally sets a threshold level for Mos protein, which must be exceeded for Mos to activate the MAPK signaling pathway and induce oocyte maturation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.