ArticleDiabetologia1998
Effect of glycaemic control on myocardial sympathetic innervation assessed by [123I]metaiodobenzylguanidine scintigraphy: a 4-year prospective study in IDDM patients.
Article in Diabetologia, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03912909 (Effects of SGLT-2 Inhibition on Sympathetic Nervous System Activity in Humans), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of SGLT-2 Inhibition on Sympathetic Nervous System Activity in Humans
Who cites it
17 citing papers in PubMed.
- Long-term effect of acetyl-L-carnitine on myocardial 123I-MIBG uptake in patients with diabetes.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2000Trial
- Impact of blood glucose control on sympathetic and vagus nerve functional status in patients with type 2 diabetes mellitus.Acta diabetologica · 2020Article
- A Comparative Assessment of Cardiovascular Autonomic Reflex Testing and CardiacInternational journal of endocrinology · 2018Article
- Microvascular dysfunction in the context of diabetic neuropathy.Current diabetes reports · 2014Review
- Concepts of scientific integrative medicine applied to the physiology and pathophysiology of catecholamine systems.Comprehensive Physiology · 2013Review
- Impact of diabetes on cardiac sympathetic innervation in patients with heart failure: a 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study.Diabetes care · 2013Article
- Article
- Obesity, diabetes and atrial fibrillation; epidemiology, mechanisms and interventions.Current cardiology reviews · 2012Review
- Neurocardiology: therapeutic implications for cardiovascular disease.Cardiovascular therapeutics · 2012Review
- Autonomic imbalance: prophet of doom or scope for hope?Diabetic medicine : a journal of the British Diabetic Association · 2011Review
- Cardiac autonomic neuropathy in patients with diabetes and no symptoms of coronary artery disease: comparison of 123I-metaiodobenzylguanidine myocardial scintigraphy and heart rate variability.European journal of nuclear medicine and molecular imaging · 2010Article
- Early autonomic dysfunction in type 1 diabetes: a reversible disorder?Diabetologia · 2009Article
- Role of interleukin-6 levels in cardiovascular autonomic dysfunction in type 2 diabetic patients.European journal of nuclear medicine and molecular imaging · 2008Article
- Sudden cardiac death in diabetes mellitus: risk factors in the Rochester diabetic neuropathy study.Journal of neurology, neurosurgery, and psychiatry · 2005Article
- Sympathetic mediated vasomotion and skin capillary permeability in diabetic patients with peripheral neuropathy.Diabetologia · 2003Article
- I-123 metaiodobenzylguanidine imaging in non-insulin-dependent diabetic patients with normal myocardial perfusion scans: new insights into their increased cardiac morbidity and mortality rates.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- MIBG imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic cardiovascular autonomic neuropathy (CAN) has been directly characterized by reduced or absent myocardial [123I]metaiodobenzylguanidine (MIBG) uptake, but there is no information available on the relationship between the myocardial adrenergic innervation defects and long-term glycaemic control. In a prospective study over a mean of 4 years we examined myocardial sympathetic innervation in 12 Type 1 (insulin-dependent) diabetic patients using MIBG scintigraphy (absolute and relative global MIBG uptake at 2 h p.i.) in conjunction with cardiovascular autonomic function tests, QTc interval, and QT dispersion. Six healthy non-diabetic subjects served as controls for the MIBG scintigraphy at baseline. HbA1c was measured twice a year. One patient, in whom MIBG accumulation was reduced maximally, died during follow up. Among the remaining patients 5 had good or borderline glycaemic control (mean HbA1c < 7.6%; Group 1), whereas 6 patients were poorly controlled (mean HbA1c > or = 7.6%; Group 2). Absolute global MIBG uptake increased from baseline to follow-up by 260 (-190-540) [median (range)] cpm/g in Group 1 and decreased by -150 (-450-224) cpm/g in Group 2 (p < 0.05 vs Group 1). Relative global MIBG uptake decreased by -1.7 (-3.4-9.4) % in Group 1 and by -4.7 (-17.4-1.3) % in Group 2 (p < 0.05 vs Group 1). No differences between the groups were noted for the changes in the automatic function tests, QTc interval, and QT dispersion. In conclusion, long-term poor glycaemic control constitutes an essential determinant in the progression of left ventricular adrenergic dysinnervation which may be prevented by near-normoglycaemia. Evaluation of susceptibility to metabolic intervention may be superior when CAN is characterized directly by MIBG scintigraphy rather than by indirect autonomic function testing.
Indexed as
Identifiers
9562349What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.