Evidence map›Paper›PMID 9655791›Full record

Trial reportJournal of applied physiology (Bethesda, Md. : 1985)1998

Abnormal oxygen uptake kinetic responses in women with type II diabetes mellitus.

J G Regensteiner, T A Bauer, J E Reusch, S L Brandenburg, J M Sippel, A M Vogelsong, S Smith, E E Wolfel, R H Eckel, W R Hiatt

Registry-linked trialAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02045290 (Metformin Therapy for Overweight Adolescents With Type 1 Diabetes), which is not on this map. Cited by 88 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02045290 phase3completedstarted 2014, after this paper: background citation

Metformin Therapy for Overweight Adolescents With Type 1 Diabetes (T1D)--Insulin Clamp Ancillary Study for Assessment of Insulin Resistance

Ran2014Enrolled37Registered outcomes3Posted comparisons0ConditionsType 1 DiabetesArmsMetformin, Placebo
PMID 15855566PMID 3113569PMID 3297886PMID 3523245PMID 3825934PMID 6754515PMID 7658949PMID 8487645PMID 8640398PMID 9669786PMID 9870469PMID 3556289other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Rosiglitazone improves insulin resistance but does not improve exercise capacity in individuals with impaired glucose tolerance: A randomized clinical study.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2024
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  15. Oxygen uptake kinetics during exercise in adults with Down syndrome.European journal of applied physiology · 2010
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  16. V.O2 Kinetics and clinical factors among patients with peripheral artery disease.Journal of cardiopulmonary rehabilitation and prevention
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

J G RegensteinerSection of Vascular Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. judy.regensteiner@uchsc.edu
T A Bauer
J E Reusch
S L Brandenburg
J M Sippel
A M Vogelsong
S Smith
E E Wolfel
R H Eckel
W R Hiatt

Funding

NCRR NIH HHS RR 501RR-00051
6 · The paper itself

Abstract

Persons with type II diabetes mellitus (DM), even without cardiovascular complications have a decreased maximal oxygen consumption (VO2 max) and submaximal oxygen consumption (VO2) during graded exercise compared with healthy controls. We evaluated the hypothesis that change in the rate of VO2 in response to the onset of constant-load exercise (measured by VO2-uptake kinetics) was slowed in persons with type II DM. Ten premenopausal women with uncomplicated type II DM, 10 overweight, nondiabetic women, and 10 lean, nondiabetic women had a VO2 max test. On two separate occasions, subjects performed 7-min bouts of constant-load bicycle exercise at workloads below and above the lactate threshold to enable measurements of VO2 kinetics and heart rate kinetics (measuring rate of heart rate rise). VO2 max was reduced in subjects with type II DM compared with both lean and overweight controls (P < 0.05). Subjects with type II DM had slower VO2 and heart rate kinetics than did controls at constant workloads below the lactate threshold. The data suggest a notable abnormality in the cardiopulmonary response at the onset of exercise in people with type II DM. The findings may reflect impaired cardiac responses to exercise, although an additional defect in skeletal muscle oxygen diffusion or mitochondrial oxygen utilization is also possible.

Indexed as

AdultAutonomic Nervous SystemBody CompositionDensitometryDiabetes MellitusDiabetes Mellitus, Type 2Echocardiography, DopplerExercise TestFemaleHeart RateHumansKineticsLactic AcidMiddle AgedObesityOxygen ConsumptionLactic Acid

Identifiers

PMID9655791

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.