ArticleThe Biochemical journal1998
Atypical protein kinase Clambda binds and regulates p70 S6 kinase.
Article in The Biochemical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 74 citations in OpenAlex.
- Protein kinase C iota (PKCι) and pVHL are both needed for lysosomal degradation of α5 integrin in renal carcinoma cells.Molecular biology reports · 2025Article
- Glyoxalase 1 and protein kinase Cλ as potential therapeutic targets for late-stage breast cancer.Oncology letters · 2021Article
- Decreased Whole-Body Fat Mass Produced by Chronic Alcohol Consumption is Associated with Activation of S6K1-Mediated Protein Synthesis and Increased Autophagy in Epididymal White Adipose Tissue.Alcoholism, clinical and experimental research · 2016Article
- Article
- Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).PloS one · 2011Article
- Article
- Phosphoinositide 3-kinase signaling in the vertebrate retina.Journal of lipid research · 2010Review
- A cell polarity protein aPKClambda is required for eye lens formation and growth.Developmental biology · 2009Article
- aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Mechano-transduction to muscle protein synthesis is modulated by FAK.European journal of applied physiology · 2009Article
- Insulin signalling downstream of protein kinase B is potentiated by 5'AMP-activated protein kinase in rat hearts in vivo.Diabetologia · 2005Article
- PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells.The Journal of clinical investigation · 2005Article
- Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes.The Biochemical journal · 2003Article
- Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex.The Biochemical journal · 2003Article
- Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization.Molecular and cellular biology · 2003Article
- The Src-family tyrosine kinase inhibitor PP1 interferes with the activation of ribosomal protein S6 kinases.The Biochemical journal · 2002Article
- Natural biology of polyomavirus middle T antigen.Microbiology and molecular biology reviews : MMBR · 2001Review
- MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling.Molecular and cellular biology · 2001Article
- Atypical protein kinases Clambda and -zeta associate with the GTP-binding protein Cdc42 and mediate stress fiber loss.Molecular and cellular biology · 2000Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
p70 S6 kinase (p70 S6K) has been implicated in the regulation of cell cycle progression. However, the mechanism of its activation is not fully understood. In the present work, evidence is provided that an atypical protein kinase C (PKC) isotype, PKClambda, is indispensable, but not sufficient, for the activation of p70 S6K. Both the regulatory and kinase domains of PKClambda associate directly with p70 S6K. Overexpression of the kinase domain without kinase activity or the regulatory domain of PKClambda results in the suppression of the serum-induced activation of p70 S6K. In addition, two types of dominant-negative mutants of PKClambda, as well as a kinase-deficient mutant of p70 S6K, suppress serum-induced DNA synthesis and E2F activation. The overexpresion of the active form of PKClambda, however, fails to activate p70 S6K. These results suggest that PKClambda is a mediator in the regulation of p70 S6K activity and plays an important role in cell cycle progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.