← Statins × cardiovascular events

TrialAnnals of internal medicine1998

Effect of pravastatin on cardiovascular events in older patients with myocardial infarction and cholesterol levels in the average range. Results of the Cholesterol and Recurrent Events (CARE) trial.

S J Lewis et al.PubMed ↗Publisher ↗

What the trial testedrandomised · 1,283 people · 1998

Randomised comparison

Increased cardiovascular events

+9.00percentage points+4.00 to +13.0

As reported

difference 9.0 percentage points, 95% CI 4.00–13.0

Randomised comparison

Reduced cardiovascular events

−2.90percentage points−4.50 to −0.30

As reported

difference −2.90 percentage points, 95% CI −4.50 to −0.30

No range given

Reported lower cardiovascular events, no range given

−32.0percentage points

As reported

difference −32.0 %, no interval

No range given

Reported lower cardiovascular events, no range given

−40.0percentage points

As reported

RR −40.0 %, no interval

Four numbers in the abstract

the abstract, start to end

… of pravastatin recipients (difference, 9.0 percentage points [95% CI, 4 to 13 percentage points]; relative risk reduction, 32%; P < 0.001).

… pravastatin group (absolute reduction, 2.9 percentage points [CI, 0.3 to 4.5 percentage points]; relative reduction, 40%; P = 0.03).

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
Cardiovascular events
9.04.00–13.0
Cardiovascular events
−32.0
Cardiovascular events
−2.90−4.50 to −0.30
Cardiovascular events
RR −40.0
StatinsCardiovascular events

Statins × cardiovascular eventshelps?replicated

unlikelylikely
0.860.85 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 9841599