ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association1998
Insulin resistance precedes microalbuminuria in patients with insulin-dependent diabetes mellitus.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02045290 (Metformin Therapy for Overweight Adolescents With Type 1 Diabetes), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metformin Therapy for Overweight Adolescents With Type 1 Diabetes (T1D)--Insulin Clamp Ancillary Study for Assessment of Insulin Resistance
Who cites it
26 citing papers in PubMed, 83 citations in OpenAlex.
- A pilot study on measured insulin sensitivity and estimated glucose disposal rates in adults with type 1 diabetes and diabetic kidney disease.Endocrine · 2026Article
- Insulin Resistance in Type 1 Diabetes: Pathophysiological, Clinical, and Therapeutic Relevance.Endocrine reviews · 2025Review
- Lessons learned from the FinnDiane Study: Epidemiology and metabolic risk factors for diabetic kidney disease in type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2025Review
- Insulin sensitivity estimates and their longitudinal association with coronary artery disease in type 1 diabetes. Does it matter?Cardiovascular diabetology · 2024Article
- Estimated glucose disposal rate is associated with retinopathy and kidney disease in young people with type 1 diabetes: a nationwide observational study.Cardiovascular diabetology · 2023Observational
- Metabolomics of Type 1 and Type 2 Diabetes: Insights into Risk Prediction and Mechanisms.Current diabetes reports · 2022Review
- Urinary metabolite profiling and risk of progression of diabetic nephropathy in 2670 individuals with type 1 diabetes.Diabetologia · 2022Observational
- SHIPping out diabetes-Metformin, an old friend among new SHIP2 inhibitors.Acta physiologica (Oxford, England) · 2020Review
- Insulin: Trigger and Target of Renal Functions.Frontiers in cell and developmental biology · 2020Review
- Lipid mediators of insulin signaling in diabetic kidney disease.American journal of physiology. Renal physiology · 2019Review
- Deficient Insulin-mediated Upregulation of the Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased Adenosine in Diabetic Glomerulopathy.Scientific reports · 2017Article
- The dose-response effect of insulin sensitivity on albuminuria in children according to diabetes type.Pediatric nephrology (Berlin, Germany) · 2016Observational
- Leisure-time physical activity and development and progression of diabetic nephropathy in type 1 diabetes: the FinnDiane Study.Diabetologia · 2015Article
- Insulin resistance is associated with the development of albuminuria in Korean subjects without diabetes.Endocrine · 2015Article
- Insulin signaling: implications for podocyte biology in diabetic kidney disease.Current opinion in nephrology and hypertension · 2015Article
- Lipid biology of the podocyte--new perspectives offer new opportunities.Nature reviews. Nephrology · 2014Review
- Normoglycemic diabetic nephropathy: the role of insulin resistance.Case reports in nephrology and urology · 2014Article
- Podocytes, signaling pathways, and vascular factors in diabetic kidney disease.Advances in chronic kidney disease · 2014Review
- Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy.Diabetes · 2014Article
- Podocytopathy in diabetes: a metabolic and endocrine disorder.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsulin resistance has been associated with hypertension and with renal complications in patients with type 1 diabetes mellitus. Causal relationships have not been fully explained.
methodsWe investigated whether insulin resistance precedes microalbuminuria by measuring insulin resistance with a euglycaemic clamp in combination with indirect calorimetry in 16 uncomplicated type 1 diabetic patients and in six healthy control subjects. The patients had over 10 year duration of diabetes, and were expected to experience either a complication-free or complicated disease course within the next few years. They have thereafter been followed for the development of microalbuminuria for 3 years.
resultsIn a euglycaemic insulin clamp glucose disposal was lower in diabetic patients compared with control subjects (7.5 +/- 2.9 and 12.6 +/- 2.0 mg/kg LBM/min; P<0.002), mainly due to impaired glucose storage (4.3 +/- 2.3 vs 8.6 +/- 1.6 mg/kg LBM/min; P<0.001). Three years later seven IDDM patients had albumin excretion rate over 30 mg/24 h; glucose disposal (5.5 +/- 2.1 vs 9.0 +/- 2.2 mg/kg LBM/min; P<0.01) had been lower in patients who developed microalbuminuria compared with those who remained normoalbuminuric.
conclusionsInsulin resistance predicts the increment in urinary albumin excretion. Insulin resistance depends mainly on impaired glucose storage in uncomplicated IDDM.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.