ArticleAmerican journal of human genetics1999
A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus.
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 105 citations in OpenAlex.
- Comorbid psoriasis-bipolar disorder successfully treated with apremilast: much more than a mere coincidence?General psychiatry · 2020Article
- A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.Journal of affective disorders · 2016Article
- Fine mapping of candidate regions for bipolar disorder provides strong evidence for susceptibility loci on chromosomes 7q.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- Lithium: a key to the genetics of bipolar disorder.Genome medicine · 2009Article
- Neurotransmission and bipolar disorder: a systematic family-based association study.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Article
- Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata.American journal of human genetics · 2007Article
- Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q.American journal of human genetics · 2005Article
- Genetics of major mood disorders.Psychiatry (Edgmont (Pa. : Township)) · 2004Article
- Identification of a locus for type I punctate palmoplantar keratoderma on chromosome 15q22-q24.Journal of medical genetics · 2003Article
- A genomewide screen of 345 families for autism-susceptibility loci.American journal of human genetics · 2003Article
- Review of bipolar molecular linkage and association studies.Current psychiatry reports · 2002Review
- Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features.Nature genetics · 2002Article
- Genomewide linkage analysis of celiac disease in Finnish families.American journal of human genetics · 2002Article
- A genomewide screen for autism susceptibility loci.American journal of human genetics · 2001Article
- Genetics of bipolar affective disorder.Current psychiatry reports · 2000Review
- Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype.American journal of human genetics · 2000Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
Previously, we demonstrated evidence of linkage to bipolar affective disorder (BP) in a single large, multigenerational family with a LOD score of 3.41 at the PFKL locus on chromosome 21q22.3. Additional families showed little support for linkage to PFKL under homogeneity or heterogeneity, in that study. We have expanded on that analysis, with 31 microsatellite markers at an average marker spacing of </=2 cM, in the largest multigenerational BP pedigree series reported to date. A two-point heterogeneity (alpha=0.5) LOD score of 3.35 (P<.000156) was found at the D21S1260 locus, 5 cM proximal to PFKL. Polylocus analysis with a cluster of three neighboring markers was consistent with these results (PL-HetLOD = 3.25). In the design of this study, 373 individuals from 40 families (from a total set of 1,508 individuals in 57 families) were chosen, as a cost-effective approach to genotyping this large sample set. Linkage analyses were performed with an "affecteds-only" method. As such, our results are based solely on genetic information from affected individuals, without assumptions about the disease-locus genotypes of the unaffecteds. Furthermore, for ease of comparison, this study was performed with the same approach as a 10-cM genome scan for BP loci, the results of which will be reported elsewhere.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.