Evidence map›Paper›PMID 12552501›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2003

Factors associated with medication-related problems in ambulatory hemodialysis patients.

Harold J Manley, Marcy L McClaran, Debra K Overbay, Marcia A Wright, Gerald M Reid, Walter L Bender, Timothy K Neufeld, Sudarshan Hebbar, Richard S Muther

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03663049 (Trial of Statin Holiday in Patients Receiving Maintenance Dialysis), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03663049 phase4unknown statusstarted 2018, after this paper: background citation

Trial of Statin Holiday in Patients Receiving Maintenance Dialysis

Ran2018Enrolled30Registered outcomes5Posted comparisons0ConditionsCardiovascular Diseases, ESRDArmsdiscontinue statin
PMID 23975627PMID 19332456PMID 21663949PMID 24552851PMID 25074839PMID 25278548PMID 25864928PMID 26255306PMID 28416321PMID 28464924PMID 8747848PMID 9214400other papers from this trial
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3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Interventions for chronic kidney disease-associated restless legs syndrome.The Cochrane database of systematic reviews · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Harold J ManleyUniversity of Missouri-Kansas City, School of Pharmacy; Dialysis Clinic, Inc. MO, USA. manleyh@umkc.edu
Marcy L McClaran
Debra K Overbay
Marcia A Wright
Gerald M Reid
Walter L Bender
Timothy K Neufeld
Sudarshan Hebbar
Richard S Muther

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHemodialysis (HD) patients are at risk for medication-related problems. Patient characteristics associated with the number of medication-related problems in HD patients have not been investigated.

methodsPatient records were reviewed to identify medical problems, prescribed medications, medication indication(s), and medication-related problems. Medication classes and medication-related problems were compared between patients with and without diabetes mellitus (DM). Correlations were performed to determine whether associations exist between medication-related problems, number of medications, number of medication doses per day, number of comorbid conditions, patient age, and duration of end-stage renal disease while controlling for DM status.

resultsMedical records of 133 patients were evaluated. Patients were 60.5 +/- 15.2 years old, prescribed 11.0 +/- 4.2 medications, and had 6.0 +/- 2.3 comorbidities. Medication-related problems were identified in 97.7% of patients. Four hundred seventy-five medication-related problems were identified, averaging 3.6 +/- 1.8 medication-related problems per patient. Patients with DM had more medication-related problems identified than those without DM (303 versus 172 medication-related problems, respectively; P < 0.05). Medication-related problems correlated positively with number of patient comorbidities (P < 0.001).

conclusionMedication-related problems are prevalent in virtually all HD patients. The number of medication-related problems in an individual patient increases as the number of comorbid conditions increases. The most frequent medication-related problems were drug without indication (30.9%), laboratory (27.6%), indication without drug use (17.5%), and dosing errors (15.4%). Patients with DM are at increased risk for medication-related problems. Health care providers taking care of HD patients should be aware of this problem, and efforts to avoid or resolve medication-related problems should be undertaken at all HD clinics.

Indexed as

AdultAgedAged, 80 and overAge FactorsAnemiaCardiovascular DiseasesDiabetes ComplicationsDiabetes MellitusFemaleGastrointestinal DiseasesHumansInfectionsKidney Failure, ChronicMaleMedication ErrorsMental Disorders

Identifiers

PMID12552501

What Socratic holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.