Other lipid agents × cardiovascular events

TrialLancet (London, England)2011

The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial.

Colin Baigent et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 10,000 people · 2011

Randomised comparison

Reduced cardiovascular events

−25%−40% to −6%

3 in 100 instead of 4

Bigger than 6 in 10 for cardiovascular events

As reported

RR 0.75, 95% CI 0.60–0.94

Randomised comparison

Lowered lipids

−17%−26% to −6%

Bigger than 4 in 10 on the map

As reported

IRR 0.83, 95% CI 0.74–0.94

Randomised comparison

Reduced cardiovascular events

−21%−32% to −7%

Bigger than 5 in 10 for cardiovascular events

As reported

RR 0.79, 95% CI 0.68–0.93

Range includes no effect

No clear effect on cardiovascular events

−8%−24% to +11%

Bigger than 1 in 10 for cardiovascular events

As reported

RR 0.92, 95% CI 0.76–1.11

Four numbers in the abstract

the abstract, start to end

disease (213 [4.6%] vs 230 [5.0%]; RR 0.92, 95% CI 0.76-1.11; p=0.37) and there were significant reductions in non-haemorrhagic stroke (131 [2.8%] vs 174 [3.8%]; RR 0.75, 95% CI 0.60-0.94; p=0.01) and arterial revascularisation procedures (284 [6.1%] vs 352 [7.6%]; RR 0.79, 95% CI 0.68-0.93; p=0.0036).

vs 619 [13.4%] placebo; rate ratio [RR] 0.83, 95% CI 0.74-0.94; log-rank

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
RR 0.920.76–1.11
Cardiovascular events
RR 0.750.60–0.94
Lipids
IRR 0.830.74–0.94
Cardiovascular events
RR 0.790.68–0.93
StatinsOther lipid agentsLipidsCardiovascular events

Other lipid agents × lipidshelps?mixed

unlikelylikely
0.500.50 without it

Statins × lipidshelps?mixed

unlikelylikely
0.500.50 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 21663949