ReviewArchives of internal medicine2004
Conceptual foundations of the UCSD Statin Study: a randomized controlled trial assessing the impact of statins on cognition, behavior, and biochemistry.
Review in Archives of internal medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00330980. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Statins and Noncardiovascular Endpoints
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Statins, mood, sleep, and physical function: a systematic review.European journal of clinical pharmacology · 2014Pooled it
- Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation.Vascular health and risk management · 2014Trial
- Effects of statins on energy and fatigue with exertion: results from a randomized controlled trial.Archives of internal medicine · 2012Trial
- Association between more frequent chocolate consumption and lower body mass index.Archives of internal medicine · 2012Trial
- Reduction in blood pressure with statins: results from the UCSD Statin Study, a randomized trial.Archives of internal medicine · 2008Trial
- The UCSD Statin Study: a randomized controlled trial assessing the impact of statins on selected noncardiac outcomes.Controlled clinical trials · 2004 · on this mapTrial
- Statin-induced increase in actin polymerization modulates GPCR dynamics and compartmentalization.Biophysical journal · 2023Article
- Cholesterol Management in Neurology: Time for Revised Strategies?Journal of personalized medicine · 2022Review
- Low cholesterol is not always good: low cholesterol levels are associated with decreased serotonin and increased aggression in fish.Biology open · 2018Article
- Neuropsychiatric adverse events associated with statins: epidemiology, pathophysiology, prevention and management.CNS drugs · 2014Review
- Article
- Mood food: chocolate and depressive symptoms in a cross-sectional analysis.Archives of internal medicine · 2010Article
- Erik Rifkin, PhD: Writer, Researcher, Patient, and Citizen Advocate.The patient · 2008Article
- Neurobiology of aggression and violence.The American journal of psychiatry · 2008Review
- Combined biological tests for suicide prediction.Psychiatry research · 2007Article
- Psychiatric adverse reactions with statins, fibrates and ezetimibe: implications for the use of lipid-lowering agents.Drug safety · 2007Review
- Effects of atorvastatin on higher functions.European journal of clinical pharmacology · 2006Article
- The Association Between Reduced Inflammation and Cognitive Gains After Bariatric Surgery.Psychosomatic medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundStatin cholesterol-lowering drugs are among the most prescribed drugs in the United States. Their cardiac benefits are substantial and well supported. However, there has been persistent controversy regarding possible favorable or adverse effects of statins or of cholesterol reduction on cognition, mood, and behavior (including aggressive or violent behavior).
methodsThe literature pertaining to the relationship of cholesterol or statins to several noncardiac domains was reviewed, including the link between statins (or cholesterol) and cognition, aggression, and serotonin.
resultsThere are reasons to think both favorable and adverse effects of statins and low cholesterol on cognition may pertain; the balance of these factors requires further elucidation. A substantial body of literature links low cholesterol level to aggressive behavior; statin randomized trials have not supported a connection, but they have not been designed to address this issue. A limited number of reports suggest a connection between reduced cholesterol level and reduced serotonin level, but more information is needed with serotonin measures that are practical for clinical use. Whether lipophilic and hydrophilic statins differ in their impact should be assessed.
conclusionThere is a strong need for randomized controlled trial data to more clearly establish the impact of hydrophilic and lipophilic statins on cognition, aggression, and serotonin, as well as on other measures relevant to risks and quality-of-life impact in noncardiac domains.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.