← Statins × blood pressure

TrialArchives of internal medicine2008

Reduction in blood pressure with statins: results from the UCSD Statin Study, a randomized trial.

Beatrice A Golomb et al.PubMed ↗Full text ↗Publisher ↗

The primary results report of NCT00330980.

  • Statinslooks good hereLower systolic blood pressure, no range given, lower diastolic blood pressure, no range given.No ranges given.
  • Simvastatin and pravastatinno clear effectLower SBP and DBP, no range given.No ranges given.

What the trial testedas reported · 2008

No range given

Reported lower systolic blood pressure, no range given

−2.20mm Hg

statins vs placebo

As reported

difference −2.20 mm Hg, no interval · the paper's word: SBP

No range given

Reported lower diastolic blood pressure, no range given

−2.40mm Hg

statins vs placebo

As reported

difference −2.40 mm Hg, no interval · the paper's word: DBP

+1 more in the walkthrough ↓

Who was studied, and how

1,000people in the Statins and Noncardiovascular Endpoints trial, from 2000
of them with hypertension, in this paper

The trial randomly assignedassigned by chance

statins
placebo

Reported lower systolic blood pressure, no range given−2.20

Reported lower diastolic blood pressure, no range given−2.40

randomised

Among subjects with full follow-up, and without potential for influence by BP medications (ie, neither receiving nor meriting BP medications), the trial randomly assignedassigned by chance

simvastatin and pravastatin
placebo

Reported lower SBP and DBP, no range given−2.40

randomised

the abstract, start to end

… reduced BP relative to placebo,by 2.2 mm Hg for SBP (P=.02) and 2.4 mm Hg for DBP (P<.001) in ITT …

Blood pressure reductions ranged from 2.4 to 2.8 mm Hg for both SBP and …

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
SBPstatins vs placebo
−2.20
DBPstatins vs placebo
−2.40
SBP and DBPsimvastatin and pravastatin vs placebo, in subjects with full follow-up, and without potential for influence by BP medications (ie, neither receiving nor meriting BP medications)
−2.40
StatinsBlood pressure

Statins × blood pressurehelps?replicated

unlikelylikely
0.800.50 without it
← favours comparatorfavours treatment →
more certainless certain
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50 papers cite it

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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 18413554