Trial reportThe Journal of pediatrics2006
Insulin dynamics predict body mass index and z-score response to insulin suppression or sensitization pharmacotherapy in obese children.
Trial report in The Journal of pediatrics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Prevention and treatment of pediatric obesity: an endocrine society clinical practice guideline based on expert opinion.The Journal of clinical endocrinology and metabolism · 2008Guideline
- Effects of metformin on body weight and body composition in obese insulin-resistant children: a randomized clinical trial.Diabetes · 2011 · on this mapTrial
- Intraperitoneal fat and insulin resistance in obese adolescents.Obesity (Silver Spring, Md.) · 2010Trial
- Trial
- Addition of metformin to a lifestyle modification program in adolescents with insulin resistance.The Journal of pediatrics · 2008 · on this mapTrial
- Hyperinsulinemia is a probable trigger for weight gain and hyperphagia in individuals with Prader-Willi syndrome.Obesity science & practice · 2023Article
- Adipose Tissue Insulin Resistance Is Not Associated With Changes in the Degree of Obesity in Children and Adolescents.The Journal of clinical endocrinology and metabolism · 2023Observational
- [Clinical guidelines «Obesity in children»].Problemy endokrinologii · 2021Article
- Hypothalamic Obesity: 4 Years of the International Registry of Hypothalamic Obesity Disorders.Obesity (Silver Spring, Md.) · 2018Article
- A longitudinal study of serum insulin and insulin resistance as predictors of weight and body fat gain in African American and Caucasian children.International journal of obesity (2005) · 2017Article
- Late endocrine effects of childhood cancer.Nature reviews. Endocrinology · 2016Review
- Treatment of obesity in children and adolescents.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2012Article
- Long-term effects of metformin and lifestyle modification on nonalcoholic Fatty liver disease obese adolescents.Journal of obesity · 2010Article
- Review
- Insulin resistance, hyperinsulinemia, and energy intake in overweight children.The Journal of pediatrics · 2008Article
- Use of somatostatin analogues in obesity.Drugs · 2008Review
- Insulin resistance in children and adolescents.Reviews in endocrine & metabolic disorders · 2006Review
- Pediatric endocrine disorders of energy balance.Reviews in endocrine & metabolic disorders · 2005Review
Corrections and comments
- Commented on by
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo assess the use of oral glucose tolerance testing (OGTT) to predict efficacy of insulin sensitization (metformin) or suppression (octreotide) because insulin resistance and insulin hypersecretion may impact pharmacotherapeutic efficacy in obese children. STUDY
designForty-three and 24 obese children, with and without central nervous system (CNS) insult, underwent OGTT. Insulin sensitivity was expressed as composite insulin sensitivity index (CISI), and secretion as corrected insulin response (CIRgp). Those without CNS insult received metformin (weight-based dosing) for 6 to 16 months. Those with CNS insult received octreotide SQ 15 microg/kg/d for 6 months. Body mass index (BMI) and z-score responses were modeled using CIRgp and CISI.
resultsMetformin: With CIRgp and CISI = 1, BMI z-score in white children declined by 0.23 over the first 4 months (P < .001), and by 0.14 over the next year (P = .33). Each 2-fold increase in CIRgp or CISI attenuated BMI z-score reduction, but with wide uncertainty (P = .24). Black children exhibited little response. Octreotide: With CIRgp and CISI = 1, BMI z-score decreased by 0.23 in the first 4 months (P = .052). Efficacy was dependent on an interaction between CIRgp and CISI (P = .051).
conclusionsEfficacy of metformin was predicted by pretreatment insulin resistance. Efficacy of octreotide was predicted by insulin hypersecretion and sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.