Evidence map›Paper›PMID 16567818›Full record

ArticleDiabetes care2006

High risk of cardiovascular disease in patients with type 1 diabetes in the U.K.: a cohort study using the general practice research database.

Sabita S Soedamah-Muthu, John H Fuller, Henrietta E Mulnier, Veena S Raleigh, Ross A Lawrenson, Helen M Colhoun

3 registry-linked trialsOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Diabetes care, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 156 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 7 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04133922 early_phase1withdrawnstarted 2019, after this paper: background citation

Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes

Ran2019Enrolled0Registered outcomes5Posted comparisons0ConditionsInsulin Sensitivity/Resistance, Type 1 DiabetesArmsDextrose 20 % in Water, GLP-1, Insulin
PMID 27295427PMID 27436611PMID 28479155PMID 23657563PMID 28912645PMID 29139080PMID 29449137PMID 29671082PMID 26455399PMID 25998289PMID 25660575PMID 3825934other papers from this trial
Open the trial in the graph
NCT01337947 completednot on this mapstarted 2011, after this paper: background citation

The Impact of Fitness on Vascular Dysfunction in Adolescents With Type 1 Diabetes

TypeobservationalSponsorUniversity of VirginiaRan2011 to 2013Enrolled32ConditionsType 1 DiabetesArmsDefinity microbubbles
NCT05790785 recruitingnot on this mapstarted 2024, after this paper: background citation

Understanding Vascular Complications in Children From Type 1 Diabetes Diagnosis

TypeobservationalSponsorUniversity of British ColumbiaRan2024 to 2027Enrolled150ConditionsType 1 Diabetes, Cardiovascular Complications, Child, Adolescent
3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 7 syntheses or guidelines pooled it, 390 citations in OpenAlex.

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  7. Overweight and obesity in youth with type 1 diabetes.Annual review of nursing research · 2013
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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sabita S Soedamah-MuthuDepartment of Epidemiology and Public Health, Royal Free and University College London Medical School, UK. s.s.soedamah-muthu@umcutrecht.nl
John H Fuller
Henrietta E Mulnier
Veena S Raleigh
Ross A Lawrenson
Helen M Colhoun
University College Dublin · IEUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo estimate the absolute and relative risk of cardiovascular disease (CVD) in patients with type 1 diabetes in the U.K. RESEARCH DESIGN AND

methodsSubjects with type 1 diabetes (n = 7,479) and five age- and sex-matched subjects without diabetes (n = 38,116) and free of CVD at baseline were selected from the General Practice Research Database (GPRD), a large primary care database representative of the U.K. population. Incident major CVD events, comprising myocardial infarction, acute coronary heart disease death, coronary revascularizations, or stroke, were captured for the period 1992-1999.

resultsThe hazard ratio (HR) for major CVD was 3.6 (95% CI 2.9-4.5) in type 1 diabetic men compared with those without diabetes and 7.7 (5.5-10.7) in women. Increased HRs were found for acute coronary events (3.0 and 7.6 in type 1 diabetic men and women, respectively, versus nondiabetic subjects), coronary revascularizations (5.0 in men, 16.8 in women), and for stroke (3.7 in men, 4.8 in women). Type 1 diabetic men aged 45-55 years had an absolute CVD risk similar to that of men in the general population 10-15 years older, with an even greater difference in women.

conclusionsDespite advances in care, these data show that absolute and relative risks of CVD remain extremely high in patients with type 1 diabetes. Women with type 1 diabetes continue to experience greater relative risks of CVD than men compared with those without diabetes.

Indexed as

AdultAgedCardiovascular DiseasesCohort StudiesDiabetes Mellitus, Type 1FemaleHumansMaleMiddle AgedPrevalenceProportional Hazards ModelsRetrospective StudiesRisk AssessmentSex FactorsUnited Kingdom

Identifiers

PMID16567818
OpenAlexW2098959597

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.