Evidence map›Paper›PMID 17345122›Full record

ReviewWorld journal of surgery2007

Peripheral arterial occlusive disease: magnetic resonance imaging and the role of aggressive medical management.

Alan B Lumsden, Terry W Rice, Changyi Chen, Wei Zhou, Peter H Lin, Paul Bray, Joel Morrisett, Vijay Nambi, Christie Ballantyne

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in World journal of surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00687076 (Effect of Lipid Modification on Peripheral Arterial Disease After Endovascular Intervention), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00687076 phase4completednot on this map

Effect of Lipid Modification on Peripheral Arterial Disease After Endovascular Intervention ("The ELIMIT Trial")

TypeinterventionalSponsorBaylor College of MedicineRan2004 to 2010Enrolled102ConditionsPeripheral Arterial DiseaseArmsEzetimibe, Niaspan, Statin therapy, Standard care, Aspirin
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery.The Cochrane database of systematic reviews · 2013 · on this map
    Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Patient-Specific Flow Descriptors and Normalized wall index in Peripheral Artery Disease: a Preliminary Study.Computer methods in biomechanics and biomedical engineering. Imaging & visualization · 2018
    Article
  9. Article
  10. Article
  11. Article
  12. The association of lesion eccentricity with plaque morphology and components in the superficial femoral artery: a high-spatial-resolution, multi-contrast weighted CMR study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2010
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Alan B LumsdenMethodist DeBakey Heart Center, Baylor College of Medicine, 1709 Dryden Street, Suite 1500, Houston, Texas 77030, USA. alumsden@bcm.tmc.edu
Terry W Rice
Changyi Chen
Wei Zhou
Peter H Lin
Paul Bray
Joel Morrisett
Vijay Nambi
Christie Ballantyne
Baylor College of Medicine · US

Funding

Effect of lipid modification on peripheral arterial disease (PAD)R01HL075824 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL · 2003 to 2007
$4.4M
NHLBI NIH HHS R01 HL75824
6 · The paper itself

Abstract

Atherosclerosis accounts for most peripheral arterial occlusive disease (PAD). Although many of the risk factors for atherosclerotic coronary artery disease (CAD) such as hyperlipidemia have been identified as risk factors for peripheral arterial disease, strong evidence is lacking that risk factor modification is effective in halting progression or improving outcomes. A better understanding is needed regarding the clinical and pathophysiologic responses to risk factor modification. This review describes current advances in the medical management for PAD including lipid modification antiplatelet therapy, angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, exercise, and endovascular intervention. In addition, we discuss our active ELIMIT Trial (Effect of Lipid Modification on Peripheral Arterial Disease after Endovascular Intervention). We test the hypothesis that an aggressive regimen of serum lipid modification will inhibit the progression of atherosclerosis in femoral arteries and reduce the incidence of restenosis of femoral arteries following endovascular stenting by decreasing thrombosis and inflammation. This study will provide a novel strategy for retarding or preventing progression of atherosclerosis and re-stenosis of peripheral arterial disease following arterial revascularization procedures. Importantly, our magnetic resonance imaging studies will provide quantitative data on the vascular lesions in PAD. These studies will advance our understanding of the molecular mechanisms of inflammation and thrombosis associated with aggressive lipid modification.

Indexed as

Adrenergic beta-AntagonistsAlgorithmsAngiotensin-Converting Enzyme InhibitorsArterial Occlusive DiseasesAtherosclerosisClinical Trials as TopicDisease ProgressionExercise TherapyFemoral ArteryHumansMagnetic Resonance ImagingPeripheral Vascular DiseasesPlatelet Aggregation InhibitorsRisk FactorsAdrenergic beta-AntagonistsAngiotensin-Converting Enzyme InhibitorsPlatelet Aggregation Inhibitors

Identifiers

PMID17345122
OpenAlexW2100150248

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.