SynthesisFertility and sterility2008
Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence.
Synthesis in Fertility and sterility, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 139 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of the Combination Liraglutide and Metformin on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With Polycystic Ovarian Syndrome, Obesity and Infertility
Pregnancy Outcomes in Overweight and Obese Women With a History of Recurrent Pregnancy Loss Randomized to a Structured Weight Loss Program Versus Routine Weight-Loss Counseling: A Pilot Study
Who cites it
139 citing papers in PubMed, 8 syntheses or guidelines pooled it, 540 citations in OpenAlex.
- Effect of weight loss before in vitro fertilization in women with obesity or overweight and infertility: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Systematic review with meta-analysis: Non-alcoholic fatty liver disease and the association with pregnancy outcomes.Clinical and molecular hepatology · 2022Pooled it
- The effects of bariatric surgery on periconception maternal health: a systematic review and meta-analysis.Human reproduction update · 2021Pooled it
- Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss.Scientific reports · 2021Pooled it
- Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis.Human reproduction update · 2020Pooled it
- Obesity and gynaecological and obstetric conditions: umbrella review of the literature.BMJ (Clinical research ed.) · 2017Pooled it
- IVF outcomes in obese donor oocyte recipients: a systematic review and meta-analysis.Human reproduction (Oxford, England) · 2013Pooled it
- Antenatal interventions for reducing weight in obese women for improving pregnancy outcome.The Cochrane database of systematic reviews · 2013Pooled it
- Inflammatory and metabolic markers in relation to outcome of in vitro fertilization in a cohort of predominantly overweight and obese women.Scientific reports · 2022Trial
- Effects of preconception lifestyle intervention in infertile women with obesity: The FIT-PLESE randomized controlled trial.PLoS medicine · 2022 · on this mapTrial
- The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity.Frontiers in endocrinology · 2022Trial
- Benefit of Delayed Fertility Therapy With Preconception Weight Loss Over Immediate Therapy in Obese Women With PCOS.The Journal of clinical endocrinology and metabolism · 2016Trial
- Design of lifestyle intervention trials to prevent excessive gestational weight gain in women with overweight or obesity.Obesity (Silver Spring, Md.) · 2016Trial
- Use of Glucagon-Like Peptide-1 Receptor Agonists in Women with Type 2 Diabetes Before Pregnancy: Addressing the Dilemma in A Real-World Setting.Current diabetes reports · 2026Review
- Interaction between triglyceride-glucose index and body mass index on pregnancy loss in Chinese women with polycystic ovary syndrome: a secondary analysis of a randomized clinical trial.Reproductive biology and endocrinology : RB&E · 2026Article
- Mendelian randomization reveals the associations between modifiable risk factors and intermediate phenotypes and spontaneous abortion.BMC pregnancy and childbirth · 2026Article
- A multivariable risk prediction model for pregnancies of uncertain viability without a fetal pole: a prospective cohort study.Frontiers in medicine · 2026Article
- The Link Between Spontaneous Abortion and Vitamin E may be Influenced by the Fat Mass and Obesity-Associated Gene, a Case-Control Study.Health science reports · 2025Article
- Effects of pre-pregnancy BMI and gestational weight gain on pregnancy and neonatal outcomes in Poland.Scientific reports · 2025Article
- Pharmacotherapy for obesity: are we ready to select, tailor and combine pharmacotherapy to achieve more ambitious goals?Frontiers in endocrinology · 2025Review
79 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association between obesity and miscarriage.
designMeta-analysis.
settingThe Academic Unit of Reproductive and Developmental Medicine, The University of Sheffield, United Kingdom. PATIENT(S): Obese and overweight patients who had miscarriage after spontaneous or assisted conception, compared with patients with a normal body mass index. INTERVENTION(S): A systematic review was conducted for all relevant articles in MEDLINE from 1964 to September 2006 and in EMBASE from 1974 to September 2006, using a combination of the following search terms: obesity/obes*/obes$/BMI, miscarriage/abortion/pregnancy, IVF, clomifene/clomiphene, gonadotrophins/gonadotrop*/gonadotrop$. MAIN OUTCOME MEASURE(S): Pregnancy loss at <20 weeks of gestation. RESULT(S): Sixteen studies were included in the meta-analysis. Patients with a body mass index of > or =25 kg/m(2) had significantly higher odds of miscarriage, regardless of the method of conception (odds ratio, 1.67; 95% confidence interval, 1.25-2.25). Subgroup analysis from a limited number of studies suggested that this group of women may also have significantly higher odds of miscarriage after oocyte donation (odds ratio, 1.52; 95% confidence interval, 1.10-2.09) and ovulation induction (odds ratio, 5.11; 95% confidence interval, 1.76-14.83). There was no evidence for increased odds of miscarriage after IVF-intracytoplasmic sperm injection. CONCLUSION(S): There is evidence that obesity may increase the general risk of miscarriage. However, there is insufficient evidence to describe the effect of obesity on miscarriage in specific groups such as those conceiving after assisted conception.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.