Evidence mapPaperPMID 18165348Full record

ArticleDiabetes care2008

Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: update regarding thiazolidinediones: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes.

David M Nathan, John B Buse, Mayer B Davidson, Ele Ferrannini, Rury R Holman, Robert Sherwin, Bernard Zinman

2 registry-linked trialsAbstract readConsensus Statement
PubMed Publisher
In one paragraph

Article in Diabetes care, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 59 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 3 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03419624 phase3terminatedstarted 2018, after this paper: background citation

A 28-week, Multi-center Randomized, Double-blind, Placebo-controlled Study to Evaluate the Potential of Dapagliflozin Plus Exenatide in Combination With High-dose Intensive Insulin Therapy Compared to Placebo in Obese Insulin-resistant Patients With Type 2 Diabetes Mellitus (Proof-of-concept Study)

Ran2018Enrolled13Registered outcomes7Posted comparisons0ConditionsDiabetes Mellitus, Type 2, ObesityArmsDapagliflozin 10mg, Exenatide 2 mg [Bydureon], Insulin, Metformin, if taken before, Placebo injection
Open the trial in the graph
NCT00641407 phase4completednot on this map

Bedtime Insulin Glargine or Bedtime Neutral Protamine Lispro Combined With Sulfonylurea and Metformin in Type 2 Diabetes. A Randomized, Controlled Trial

TypeinterventionalSponsorUniversity of Campania Luigi VanvitelliRan2007 to 2008Enrolled100ConditionsType 2 Diabetes Mellitus, HypoglycemiaArmsNPL insulin, Insulin glargine
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David M NathanDiabetes Center, Massachusetts General Hospital, Boston, MA 02114, USA. dnathan@partners.org
John B Buse
Mayer B Davidson
Ele Ferrannini
Rury R Holman
Robert Sherwin
Bernard Zinman

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AlgorithmsDiabetes Mellitus, Type 2EuropeHumansHyperglycemiaHypoglycemic AgentsLife StyleSocieties, MedicalThiazolidinedionesUnited StatesHypoglycemic AgentsThiazolidinediones

Identifiers

PMID18165348

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.