Who was studied, and how
Four numbers in the abstract
Where each one falls
Where it lands on the map
What it changes
Among 21 other studies
6,390people with cardiovascular disease, in this paper
The trial randomly assignedassigned by chance
statins
placebo
Lowered total cholesterol−42.3
Reduced fatal cardiovascular events−19%
Reduced non-fatal cardiovascular events−22%
randomisedthe abstract, start to end
… 6390 patients; weighted mean difference -42.28 mg/dl (1.10 mmol/l), 95% …
… studies, 23 266 patients; relative risk 0.81, 0.73 to 0.90) and non-fatal cardiovascular events (8 studies, 22 863 patients; 0.78, 0.73 to 0.84) were reduced with statins, but statins had no significant effect on all cause mortality (44 studies, 23 665 patients; 0.92, 0.82 to 1.03).
← favours treatmentfavours comparator →
could be chanceTotal cholesterolstatins vs placebo
−42.28−47.3 to −37.3
Fatal cardiovascular eventsstatins vs placebo
RR 0.810.73–0.90
Non-fatal cardiovascular eventsstatins vs placebo
RR 0.780.73–0.84
All cause mortalitystatins vs placebo
RR 0.920.82–1.03
StatinsLipidsCardiovascular eventsAll-cause mortality
Statins × cardiovascular eventshelps?replicated
unlikelylikely
0.86not counted
Statins × lipidshelps?mixed
unlikelylikely
0.50not counted
Statins × all-cause mortalityhelps?mixed
unlikelylikely
0.50not counted
← favours treatmentfavours comparator →
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