← Antihypertensives × lipids

TrialLancet (London, England)2008

Nurse-coordinated multidisciplinary, family-based cardiovascular disease prevention programme (EUROACTION) for patients with coronary heart disease and asymptomatic individuals at high risk of cardiovascular disease: a paired, cluster-randomised controlled trial.

D A Wood et al.PubMed ↗Publisher ↗

  • Intervention programme (INT)cuts both waysHigher reduced consumption of saturated fat, higher achievement of total cholesterol of less than 5 mmol/L, higher increased consumption of fruit and vegetables.Randomised, large.

What the trial testedrandomised · 1,499 people · 2008

Randomised vs usual care (UC)

Raised reduced consumption of saturated fat

+17.3percentage points+6.40 to +28.2

intervention programme (INT) vs usual care (UC)

As reported

difference 17.3 %, 95% CI 6.40–28.2

One subgroup

May have raised achievement of total cholesterol of less than 5 mmol/L in high-risk patients

+12.7percentage points+2.40 to +23.0

intervention programme (INT) vs usual care (UC), in high-risk patients

As reported

difference 12.7 %, 95% CI 2.40–23.0

Not counted

Raised increased consumption of fruit and vegetables

+37.3percentage points+18.1 to +56.5

intervention programme (INT) vs usual care (UC)

As reported

difference 37.3 %, 95% CI 18.1–56.5

Not counted

Raised increased consumption of oily fish

+8.90percentage points+0.30 to +17.5

intervention programme (INT) vs usual care (UC)

As reported

difference 8.9 %, 95% CI 0.30–17.5

Who was studied, and how

2,060people in the ALLiance for sEcondary PREvention After an Episode of Acute Coronary Syndrome. The ALLEPRE Trial trial, from 2012
1,499of them with hypertension, in this paper

The trial randomly assignedassigned by chance

intervention programme (INT)
usual care (UC)

Raised reduced consumption of saturated fat+17.3

Raised increased consumption of fruit and vegetables+37.3

Raised increased consumption of oily fish+8.90

randomised

Among high-risk patients, the trial randomly assignedassigned by chance

intervention programme (INT)
usual care (UC)

May have raised achievement of total cholesterol of less than 5 mmol/L+12.7

randomised · one subgroup

the abstract, start to end

… saturated fat (196 [55%] vs 168 [40%]; 17.3%, 6.4 to 28.2, p=0.009), and increased consumption of fruit and vegetables (680 [72%] vs 349 [35%]; 37.3%, 18.1 to 56.5, p=0.004), and oily fish (156 [17%] vs 81 [8%]; 8.9%, 0.3 to 17.5, p=0.04) at 1 …

… in change from baseline to 1 year was 12.7% (2.4 to 23.0, p=0.02) in …

← favours treatmentfavours comparator →
could be chance
Reduced consumption of saturated fatintervention programme (INT) vs usual care (UC)
17.36.40–28.2
Increased consumption of fruit and vegetablesintervention programme (INT) vs usual care (UC)
37.318.1–56.5
Increased consumption of oily fishintervention programme (INT) vs usual care (UC)
8.90.30–17.5
Achievement of total cholesterol of less than 5 mmol/Lintervention programme (INT) vs usual care (UC), in high-risk patients
12.72.40–23.0
AntihypertensivesLipidsInflammation & biomarkers

Antihypertensives × lipidshelps?replicated

unlikelylikely
0.960.50 without it

Antihypertensives × inflammation & biomarkershelps?mixed

unlikelylikely
0.00only evidence
← favours comparatorfavours treatment →
this papermore certainless certain
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4 trials

NCT025221822,060 enrolled2012NCT0366921130 enrolled2019NCT03929354208 enrolled2018NCT05285969284 enrolled2022
Full record →Abstract, authors, funding and every citing paper · PMID 18555911