Trial reportInternational journal of obesity (2005)2009
Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study.
Trial report in International journal of obesity (2005), 2009. The graph read 1 number from its abstract, feeding 1 cell of the map: it favours the comparator in 1. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
Subjects randomly allocated to pravastatin had 6% lower leptin levels (P=0.04) than those allocated to placebo.
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Where it lands on the map
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What it adds to each cell
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Statins×inflammation & biomarkers
ContradictsOpen on the map →What to test next →7 readable studies in this cell: 2 favour the treatment, 4 find no difference, 1 favour the comparator.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis.The Cochrane database of systematic reviews · 2023Pooled it
- Trial
- Prognostic Value of Adipokines in Predicting Cardiovascular Outcome: Explaining the Obesity Paradox.Mayo Clinic proceedings · 2016Trial
- Prospective, randomized, single-blind comparison of effects of 6 months' treatment with atorvastatin versus pravastatin on leptin and angiogenic factors in patients with coronary artery disease.Heart and vessels · 2012Trial
- An Updated Review on the Complex Association of Cardiovascular Disease (CVD) and Depression.Current cardiology reviews · 2025Review
- Association of Low Leptin with Poor 3-Month Prognosis in Ischemic Stroke Patients with Type 2 Diabetes.Clinical interventions in aging · 2020Observational
- Arterial Stiffness in Hypertension: an Update.Current hypertension reports · 2018Review
- Association between hyperleptinemia and cardiovascular outcomes in patients with coronary artery disease.Therapeutics and clinical risk management · 2018Article
- The role of adipokines as prognostic factors of one-year mortality in hip fracture patients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Serum Adiponectin and Leptin Concentrations in Relation to Body Fat Distribution, Hematological Indices and Lipid Profile in Humans.International journal of environmental research and public health · 2015Article
- Adipose tissue and vascular inflammation in coronary artery disease.World journal of cardiology · 2014Review
- The impact of estradiol and 1,25(OH)2D3 on metabolic syndrome in middle-aged Taiwanese males.PloS one · 2013Article
- Pivotal roles of monocytes/macrophages in stroke.Mediators of inflammation · 2013Review
- The synovial fluid adiponectin-leptin ratio predicts pain with knee osteoarthritis.Clinical rheumatology · 2010Article
- Leptinemia and its association with stroke and coronary heart disease in the Jackson Heart Study.Clinical endocrinology · 2010Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The marked sentences are the ones the graph read a number from.
objectiveTo investigate the relationships between plasma leptin and adiponectin levels and recurrent cardiovascular events (cardiovascular death, nonfatal myocardial infarction and stroke) in men with earlier acute coronary syndromes. DESIGN, SUBJECTS AND MEASUREMENTS: A nested case-control study examined circulating leptin and adiponectin levels in plasma obtained 4-6 years after entry into the Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) trial. Plasma was assayed from 184 men who suffered recurrent events within 4.4 years after blood collection and 184 matched controls who remained free of further events. The association between cardiovascular events and the explanatory variables was examined by conditional logistic regression analysis.
resultsRelative risk (RR) increased across increasing leptin quartiles; the highest quartile compared with the lowest quartile was related to the highest risk (P for trend=0.002); the increased risk remained after adjustment for risk factors (P=0.018) or for obesity (P=0.038), but in the final model (adjusted for randomized treatment, other drugs, LIPID risk score, age and body mass index), the risk was attenuated (RR=1.61, 95% CI: 0.72-3.57, P for trend=0.34). Adiponectin did not predict cardiovascular events. Subjects randomly allocated to pravastatin had 6% lower leptin levels (P=0.04) than those allocated to placebo.
conclusionPlasma leptin was a significant and independent predictor of recurrent cardiovascular events (cardiovascular death, nonfatal myocardial infarction and stroke) in men with earlier acute coronary syndromes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.