GLP-1 receptor agonists × glycemic control

TrialDiabetes care2009

One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial.

Mathijs C Bunck et al.PubMed ↗Full text ↗Publisher ↗

  • Exenatidelooks good hereHigher combined glucose- and arginine-stimulated C-peptide secretion.No ranges given.

What the trial testedas reported · 69 people · 2009

No range given

Reported lower A1C, no range given

−0.10

exenatide vs insulin glargine

As reported

difference −0.10, no interval

No range given

Reported lower body weight, no range given

−4.60kg

exenatide vs insulin glargine

As reported

difference −4.6 kg, no interval

Not counted

Probably raised combined glucose- and arginine-stimulated C-peptide secretion

2.5×2.1× to 2.9×

exenatide vs insulin glargine

Bigger than 7 in 10 for glycemic control

As reported

RR 2.46, 95% CI 2.09–2.90

Who was studied, and how

69people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

exenatide
insulin glargine

Probably raised combined glucose- and arginine-stimulated C-peptide secretion2.5×

Reported lower A1C, no range given−0.10

Reported lower body weight, no range given−4.60

randomised

the abstract, start to end

C-peptide secretion was 2.46-fold (95% CI 2.09-2.90, P <

glargine reduced A1C similarly: -0.8 +/- 0.1 and -0.7 +/- 0.2%, respectively

with insulin glargine (difference -4.6 kg, P < 0.0001). beta-Cell

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
Combined glucose- and arginine-stimulated C-peptide secretionexenatide vs insulin glargine
RR 2.462.09–2.90
A1Cexenatide vs insulin glargine
−0.10
Body weightexenatide vs insulin glargine
−4.6
GLP-1 receptor agonistsGlycemic controlBody weight & composition
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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 19196887