ArticleDiabetes2009
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.
10 registry-linked trialsAbstract readLecture
In one paragraph
Article in Diabetes, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 10 registered trials, which are not on this map. Cited by 1,222 papers, 11 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1,222citing papers in PubMed, 11 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A 16-wk, Uni-center, Randomized, Double-blind, Parallel, Phase 3b Trial to Evaluate Efficacy of Saxagliptin + Dapagliflozin vs.Dapagliflozin With Regard to EGP in T2DM With Insufficient Glycemic Control on Metformin+/-Sulfonylurea Therapy
PMID 24463448PMID 9742977PMID 21781152PMID 18726829PMID 25425451PMID 21114605PMID 24947443PMID 21205122PMID 15277443PMID 15549021PMID 17244786PMID 17613449other papers from this trial
Open the trial in the graphA Study of the Effects of Dapagliflozin on Ambulatory Aortic Pressure, Arterial Stiffness and Urine Albumin Excretion in Patients With Type 2 Diabetes
PMID 22411919PMID 24919526PMID 24745924PMID 21617109PMID 21911710PMID 21911711PMID 21955459PMID 22144689PMID 22431673PMID 22517736PMID 22528597PMID 22540323other papers from this trial
Open the trial in the graphThe Effect of Semaglutide on Disordered Eating Behaviour in Type 2 Diabetic Patients
PMID 27208320PMID 25870084PMID 36722623PMID 25330463PMID 33762313PMID 8770921PMID 7852887PMID 6961471PMID 36305323PMID 34922690PMID 34486393PMID 34286894other papers from this trial
Open the trial in the graphImpact of Pantoprazole on 24-H Glycemic Control and on Post-prandial Glucose Excursion Inpatients With Type 2 Diabetes
Effectiveness and Tolerability of Novel, Initial Triple Combination Therapy With Xigduo (Dapagliflozin Plus Metformin) and Saxagliptin vs. Conventional Stepwise add-on Therapy in Drug-naïve Patients With Type 2 Diabetes
Physiology of Disease Prevention Observational Study in Clinical Practice
Regulation of Endogenous Glucose Production by Central KATP Channels
Ethnic Dependence of the Metabolic Defects in Prediabetic Individuals: Kuwaiti Arabs Versus Indians
Effect of the Combination of Dipeptidyl Peptidase-4 Inhibitor (DPP4i) and Insulin in Comparison to Insulin on Metabolic Control and Prognosis in Hospitalized Patients With COVID-19
NCT07325435 phase4active not recruitingnot on this mapstarted 2024, after this paper: background citation
Beta Cell Function in Type 2 Diabetes in Black Patients: Differential Effects of SGLT2 Inhibitors and GLIP-Receptor Agonists
Who cites it
1,222 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- Metabolic Effects of Testosterone Replacement Therapy in Men with Functional Secondary Hypogonadism, Obesity and Type 2 Diabetes or Metabolic Syndrome: A Systematic Review.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Performance of AI in Predicting the Progression of Gestational Diabetes to Type 2 Diabetes: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Adipocyte Size, Overweight, and Insulin Resistance in Type 2 Diabetes Mellitus and the Impact of Weight Loss: A Systematic Review.Nutrients · 2026Pooled it
- Meta-analysis of the effects of exercise intervention on glucose metabolism and body composition in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2026Pooled it
- Optimal dosage of exercise combined with intermittent fasting for body composition and cardiometabolic health in adults: a systematic review and multilevel meta-analysis.Frontiers in nutrition · 2026Pooled it
- Association of triglyceride-glucose index and its related parameters with the risk of stroke: a meta-analysis.BMC neurology · 2025Pooled it
- Efficacy and Safety of Pioglitazone Add-On in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin and Dapagliflozin: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Endocrinology, diabetes & metabolism · 2025 · on this mapPooled it
- Effectiveness and Safety of Oral Quadruple Combination Therapy in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.Endocrinology and metabolism (Seoul, Korea) · 2025Pooled it
- Pooled it
- Is low birth weight associated with lower adiponectin levels? - A systematic review and meta-analysis.PloS one · 2025Pooled it
- The impact of Jinlida on blood glucose control and insulin resistance in patients with prediabetes and type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.Frontiers in endocrinology · 2025Pooled it
- Glycated Albumin Guided Therapy in Newly Diagnosed Type 2 Diabetes A Randomized Controlled Trial.Journal of diabetes · 2026Trial
- Efficacy and Safety of Fixed-Dose Combinations of Sitagliptin and Empagliflozin as Add-On to Metformin in Korean Patients With Type 2 Diabetes: A Randomised, Double-Blind, Multi-Centre, Placebo-Controlled, Phase III Trial.Diabetes, obesity & metabolism · 2026Trial
- Metformin attenuates metabolic insulin sensitivity and insulin-stimulated carbohydrate oxidation after high-intensity exercise training in adults at risk for metabolic syndrome.Diabetes, obesity & metabolism · 2026Trial
- Insulin therapy DE-intensificAtion with iGlarLixi: A phase 4, open-label, parallel-group randomised controlled trial.Diabetes, obesity & metabolism · 2026Trial
- Trial
- Trial
- The triglyceride-glucose index modulates the association between diabetes duration and insulin resistance in type 2 diabetes: a large cross-sectional study.Frontiers in endocrinology · 2026Trial
- Inadequately Controlled Type 2 Diabetes and Hypercortisolism: Improved Glycemia With Mifepristone Treatment.Diabetes care · 2025Trial
- Association of Triglyceride-Glucose Index With Different Cardiovascular Diseases in Non-Diabetic Hypertension.Journal of cellular and molecular medicine · 2025Trial
1,162 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Ralph A DefronzoDiabetes Division, University of Texas Health Science Center, San Antonio, Texas, USA. albarado@uthscsa.edu
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Adipose TissueAmyloidDiabetes Mellitus, Type 2GlucoseHumansInsulinInsulin ResistanceInsulin-Secreting CellsInsulin SecretionIslet Amyloid PolypeptideLiverMuscle, SkeletalObesityPrediabetic StateAmyloidGlucoseInsulinIslet Amyloid Polypeptide
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT02613897ClinicalTrials.gov
NCT02887677ClinicalTrials.gov
NCT06243536ClinicalTrials.gov
NCT02345239ClinicalTrials.gov
NCT02946632ClinicalTrials.gov
NCT03308773ClinicalTrials.gov
and 4 more above
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.