Thiazolidinediones × glycemic control

SynthesisEndocrinology, diabetes & metabolism2025

Efficacy and Safety of Pioglitazone Add-On in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin and Dapagliflozin: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Ubaid Khan et al.PubMed ↗Full text ↗Publisher ↗

  • Pioglitazone add-on therapylooks good hereLower HbA1c levels.Randomised, small.

What the trial testedrandomised · 885 people · 2025

Randomised vs metformin and dapagliflozin

Probably lowered HbA1c levels

−0.41−0.54 to −0.27

pioglitazone add-on therapy vs metformin and dapagliflozin

As reported

difference −0.41, 95% CI −0.54 to −0.27

Who was studied, and how

885people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

pioglitazone add-on therapy
metformin and dapagliflozin

Probably lowered HbA1c levels−0.41

randomised

the abstract, start to end

significantly reduced HbA1c levels (MD: -0.41; 95% CI: -0.54 to -0.27,

← favours treatmentfavours comparator →
could be chance
HbA1c levelspioglitazone add-on therapy vs metformin and dapagliflozin
−0.41−0.54 to −0.27
ThiazolidinedionesGlycemic control
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4 papers cite it

2025
2026
this papercites it
Full record →Abstract, authors, funding and every citing paper · PMID 40420634