Statins × all-cause mortality

TrialAtherosclerosis2009

Pravastatin and cardiovascular risk in moderate chronic kidney disease.

Haruo Nakamura et al.PubMed ↗Publisher ↗

  • Pravastatincuts both waysLower CHD, no range given, higher stroke, no range given, higher CVD, no range given.No ranges given.

What the trial testedas reported · 7,196 people · 2009

No range given

Reported lower CHD, no range given

−48.0percentage points

pravastatin vs diet alone, in moderate CKD

As reported

difference −48.0 %, no interval

No range given

Reported higher stroke, no range given

73×

pravastatin vs diet alone, in moderate CKD

Bigger than almost all for cardiovascular events

As reported

RR 73 %, no interval

No range given

Reported higher CVD, no range given

55×

pravastatin vs diet alone, in moderate CKD

Bigger than almost all for cardiovascular events

As reported

RR 55 %, no interval

No range given

Reported higher total deaths, no range given

51×

pravastatin vs diet alone, in moderate CKD

Bigger than almost all for all-cause mortality

As reported

RR 51 %, no interval · the paper's word: total mortality

Who was studied, and how

7,196people with cardiovascular disease, in this paper

Among moderate CKD, the trial randomly assignedassigned by chance

pravastatin
diet alone

Reported lower CHD, no range given−48.0

Reported higher stroke, no range given73×

Reported higher CVD, no range given55×

randomised

the abstract, start to end

pravastatin significantly reduced CHD by 48% (P=0.02), stroke by 73% (P<0.01), CVD by 55% (P<0.01), and total mortality by 51% (P=0.02).

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
CHDpravastatin vs diet alone, in moderate CKD
−48.0
Strokepravastatin vs diet alone, in moderate CKD
RR 73
CVDpravastatin vs diet alone, in moderate CKD
RR 55
Total mortalitypravastatin vs diet alone, in moderate CKD
RR 51
StatinsCardiovascular eventsAll-cause mortality
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Full record →Abstract, authors, funding and every citing paper · PMID 19423108