ArticleDiabetes2010
Cause-specific mortality trends in a large population-based cohort with long-standing childhood-onset type 1 diabetes.
Article in Diabetes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 138 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes
Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes
User Evaluation of the Guide To Goals Application - a Care Coordination Tool to Translate ADA Clinical Standards of Care for Children With T2D Into Practice
Defining the Role of Management Factors in Outcome Disparity in Pediatric T1D
Using Closed-Loop Artificial Pancreas Technology to Reduce Glycemic Variability and Subsequently Improve Cardiovascular Health in Type 1 Diabetes
Understanding Vascular Complications in Children From Type 1 Diabetes Diagnosis
Who cites it
138 citing papers in PubMed, 4 syntheses or guidelines pooled it, 356 citations in OpenAlex.
- Statins and Type 1 Diabetes: Impact on Cardiovascular Outcomes and surrogates. Systematic Review and meta-analysis.Current diabetes reports · 2025 · on this mapPooled it
- The global impact of COVID-19 pandemic on the incidence of pediatric new-onset type 1 diabetes and ketoacidosis: A systematic review and meta-analysis.Journal of medical virology · 2022Pooled it
- Glycated Hemoglobin (HbA1c) Concentrations Among Children and Adolescents With Diabetes in Middle- and Low-Income Countries, 2010-2019: A Retrospective Chart Review and Systematic Review of Literature.Frontiers in endocrinology · 2021Pooled it
- Pooled it
- Hemostatic Effects of Exercise-related Hypoglycemia in Male Persons With Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2024Trial
- Trial
- Hemoglobin A1c Variability Metrics Predict Coronary Artery Calcium and Cardiovascular Events in Type 1 Diabetes: The CACTI Study.The Journal of clinical endocrinology and metabolism · 2023Trial
- The Association of Coronary Artery Calcification With Subsequent Incidence of Cardiovascular Disease in Type 1 Diabetes: The DCCT/EDIC Trials.JACC. Cardiovascular imaging · 2019Trial
- Body mass index and adiposity indicators associated with cardiovascular biomarkers in youth with type 1 diabetes followed prospectively.Pediatric obesity · 2017Trial
- Haptoglobin 2-2 genotype and the risk of coronary artery disease in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC).Journal of diabetes and its complicationsTrial
- Obesity in Adults with Type 1 Diabetes Mellitus.Journal of obesity & metabolic syndrome · 2026Review
- Article
- Coronary plaque burden assessed by coronary CT angiography in individuals with type 1 diabetes and healthy controls.The international journal of cardiovascular imaging · 2026Article
- Statin prescription rates for prevention of atherosclerotic cardiovascular disease in adults 40-75 years old with type 1 diabetes.BMJ open · 2026Article
- Health Service Leaders' Perspectives on Type 1 Diabetes Models of Care for Children and Young Adults in Australia: A Mixed-Methods Study.Journal of diabetes research · 2026Article
- Clinical risk phenotypes in diabetes and their associations with adverse cardiovascular events: A report from the Silesia Diabetes-Heart Project.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Ketone Management in Pediatric Diabetes Centers in the USA: Current Practices and a Call for Improved Standardization.Hormone research in paediatrics · 2026Article
- Financial factors: a mixed methods survey-based study of barriers and facilitators to physical activity in type 1 diabetes.medRxiv : the preprint server for health sciences · 2025Article
- Life stage transitions for people with type 1 diabetes.The lancet. Diabetes & endocrinology · 2025Review
- Association of Sex and Other Demographic Characteristics with Hemoglobin A1c in Older Adults with Type 1 Diabetes: Cross-sectional analysis of the U.S. Premier Healthcare Database.medRxiv : the preprint server for health sciences · 2025Article
78 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveLittle is known concerning the primary cause(s) of mortality in type 1 diabetes responsible for the excess mortality seen in this population. RESEARCH DESIGN AND
methodsThe Allegheny County (Pennsylvania) childhood-onset (age < 18 years) type 1 diabetes registry (n = 1,075) with diagnosis from 1965 to 1979 was used to explore patterns in cause-specific mortality. Cause of death was determined by a mortality classification committee of at least three physician epidemiologists, based on the death certificate and additional records surrounding the death.
resultsVital status for 1,043 (97%) participants was ascertained as of 1 January 2008, revealing 279 (26.0%) deaths overall (141 females and 138 males). Within the first 10 years after diagnosis, the leading cause of death was acute diabetes complications (73.6%), while during the next 10 years, deaths were nearly evenly attributed to acute (15%), cardiovascular (22%), renal (20%), or infectious (18%) causes. After 20 years' duration, chronic diabetes complications (cardiovascular, renal, or infectious) accounted for >70% of all deaths, with cardiovascular disease as the leading cause of death (40%). Women (P < 0.05) and African Americans (P < 0.001) have significantly higher diabetes-related mortality rates than men and Caucasians, respectively. Standardized mortality ratios (SMRs) for non-diabetes-related causes do not significantly differ from the general population (violent deaths: SMR 1.2, 95% CI 0.6-1.8; cancer: SMR 1.2, 0.5-2.0).
conclusionsThe excess mortality seen in type 1 diabetes is almost entirely related to diabetes and its comorbidities but varies by duration of diabetes and particularly affects women and African Americans.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.