Metformin × cardiovascular events

SynthesisPLoS medicine2012

Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials.

Rémy Boussageon et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 13,110 people · 2012

Range includes no effect

No clear effect on deaths

−1%−25% to +31%

Smaller than almost all for all-cause mortality

As reported

RR 0.99, 95% CI 0.75–1.31 · the paper's word: All-cause mortality

Range includes no effect

No clear effect on cardiovascular events

+5%−33% to +64%

Bigger than 1 in 10 for cardiovascular events

As reported

RR 1.05, 95% CI 0.67–1.64

Range includes no effect

No clear effect on cardiovascular events

−10%−54% to +78%

Bigger than 1 in 10 for cardiovascular events

As reported

RR 0.90, 95% CI 0.46–1.78

Range includes no effect

No clear effect on cardiovascular events

−10%−26% to +9%

Bigger than 1 in 10 for cardiovascular events

As reported

RR 0.90, 95% CI 0.74–1.09

+4 more in the walkthrough ↓

Eight numbers in the abstract

the abstract, start to end

all-cause mortality, risk ratio (RR)=0.99 (95% CI: 0.75 to 1.31), and cardiovascular mortality, RR=1.05 (95% CI: 0.67 to 1.64).

all myocardial infarctions, RR=0.90 (95% CI: 0.74 to 1.09); all strokes, RR=0.76 (95% CI: 0.51 to 1.14); heart failure, RR=1.03 (95% CI: 0.67 to 1.59); peripheral vascular disease, RR=0.90 (95% CI: 0.46 to 1.78); leg amputations, RR=1.04 (95% CI: 0.44 to 2.44); and microvascular complications, RR=0.83 (95% CI: 0.59 to 1.17).

← favours treatmentfavours comparator →
could be chance
All-cause mortality
RR 0.990.75–1.31
Cardiovascular events
RR 1.050.67–1.64
Cardiovascular events
RR 0.900.46–1.78
Cardiovascular events
RR 0.900.74–1.09
Cardiovascular events
RR 0.760.51–1.14
Cardiovascular events
RR 1.030.67–1.59
Cardiovascular events
RR 1.040.44–2.44
Cardiovascular events
RR 0.830.59–1.17
MetforminCardiovascular eventsAll-cause mortality

Metformin × cardiovascular eventshelps?mixed

unlikelylikely
0.50not counted

Metformin × all-cause mortalityhelps?one trial

unlikelylikely
0.50not counted
← favours treatmentfavours comparator →
more certainless certain
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