Evidence map›Paper›PMID 23023946›Full record

ReviewJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2012

Type 2 diabetes and bone.

William D Leslie, Mishaela R Rubin, Ann V Schwartz, John A Kanis

Erratum issued 2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 167 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02473809 phase4completedstarted 2015, after this paper: background citation

The Effect of Liraglutide on Bone Turnover, Bone Mass and Bone Cell Function

Ran2015Enrolled60Registered outcomes7Posted comparisons0ConditionsDiabetes Complications, OsteoporosisArmsliraglutide, Placebo
PMID 25074632PMID 17068657PMID 7479679PMID 21372151PMID 18039776PMID 17925191other papers from this trial
Open the trial in the graph
NCT02421393 nacompletednot on this mapstarted 2018, after this paper: background citation

Study to Weigh the Effect of Exercise Training on BONE Quality and Strength (SWEET-BONE) in Type 2 Diabetes: an Exercise Intervention Program for Reducing the Risk of Fractures

TypeinterventionalSponsorMetabolic Fitness Association, ItalyRan2018 to 2024Enrolled200ConditionsType 2 DiabetesArmssupervised exercise training
3 · Its place in the literature

Who cites it

167 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Guideline
  2. Guideline
  3. Pooled it
  4. Guideline
  5. Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Pooled it
  6. Pooled it
  7. Guideline
  8. Fracture Risk After Initiation of Use of Canagliflozin: A Cohort Study.Annals of internal medicine · 2019 · on this map
    Pooled it
  9. European guidance for the diagnosis and management of osteoporosis in postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Guideline
  10. Pooled it
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Effects of Canagliflozin on Fracture Risk in Patients With Type 2 Diabetes Mellitus.The Journal of clinical endocrinology and metabolism · 2016
    Trial
  17. Defined Microbiota Modulates Host Metabolome and Skeletal Adaptation to Diet-Induced Obesity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  18. Review
  19. Article
  20. Article

107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

William D LeslieDepartment of Medicine, University of Manitoba, Winnipeg, Canada. bleslie@sbgh.mb.ca
Mishaela R Rubin
Ann V Schwartz
John A Kanis

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a growing body of research showing that diabetes is an independent risk factor for fracture. Type 2 diabetes (T2D), which predominates in older individuals and is increasing globally as a consequence of the obesity epidemic, is associated with normal or even increased dual-energy x-ray absorptiometry (DXA)-derived areal bone mineral density (BMD). Therefore, the paradoxical increase in fracture risk has led to the hypothesis that there are diabetes-associated alterations in material and structural properties. An overly glycated collagen matrix, confounded by a low turnover state, in the setting of subtle cortical abnormalities, may lead to compromised biomechanical competence. In current clinical practice, because BMD is central to fracture prediction, a consequence of this paradox is a lack of suitable methods, including FRAX, to predict fracture risk in older adults with T2D. The option of adding diabetes to the FRAX algorithm is appealing but requires additional data from large population-based cohorts. The need for improved methods for identification of fracture in older adults with T2D is an important priority for osteoporosis research.

Indexed as

Bone and BonesBone DensityDiabetes Mellitus, Type 2Fractures, BoneHumansRisk Assessment

Identifiers

PMID23023946

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.