Metformin × adverse events & safety

SynthesisPloS one2013

Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review.

Monica Franciosi et al.PubMed ↗Full text ↗Publisher ↗

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with lower pharmacokinetics & dosing

−35%−47% to −20%

Bigger than 7 in 10 on the map

As reported

OR 0.65, 95% CI 0.53–0.80

Correlation, not cause

Went with lower adverse events & safety

−27%−39% to −12%

Bigger than 6 in 10 for adverse events & safety

As reported

OR 0.73, 95% CI 0.61–0.88

Correlation, not cause

Went with lower adverse events & safety

−66%−81% to −40%

Bigger than 9 in 10 for adverse events & safety

As reported

OR 0.34, 95% CI 0.19–0.60

+4 more in the walkthrough ↓

Seven numbers in the abstract

the abstract, start to end

death [6 studies, 24,410 patients, OR:0.65, 95%CI: 0.53-0.80], all malignancies [18 studies, 561,836 patients, OR:0.73, 95%CI: 0.61-0.88], liver [8 studies, 312,742 patients, OR:0.34; 95%CI: 0.19-0.60] colorectal [12 studies, 871,365 patients, OR:0.83, 95%CI: 0.74-0.92], pancreas [9 studies, 847,248 patients, OR:0.56, 95%CI: 0.36-0.86], stomach [2 studies, 100701 patients, OR:0.83, 95%CI: 0.76-0.91], and esophagus cancer [2 studies, 100694 patients, OR:0.90, 95%CI: 0.83-0.98].

← favours treatmentfavours comparator →
could be chance
Pharmacokinetics & dosing
OR 0.650.53–0.80
Adverse events & safety
OR 0.730.61–0.88
Adverse events & safety
OR 0.340.19–0.60
Adverse events & safety
OR 0.830.74–0.92
Adverse events & safety
OR 0.830.76–0.91
Adverse events & safety
OR 0.560.36–0.86
Adverse events & safety
OR 0.900.83–0.98
MetforminAdverse events & safetyPharmacokinetics & dosing
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