Evidence map›Paper›PMID 24151290›Full record

GuidelineThe Journal of clinical endocrinology and metabolism2013

Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline.

Richard S Legro, Silva A Arslanian, David A Ehrmann, Kathleen M Hoeger, M Hassan Murad, Renato Pasquali, Corrine K Welt, Endocrine Society

Erratum issued 6 registry-linked trialsOpen access · bronzeAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 6 registered trials, which are not on this map. Cited by 690 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
690citing papers in PubMed, 17 pooled it
152.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02491333 phase3completedstarted 2015, after this paper: background citation

The Effect of Acupuncture on Insulin Sensitivity of Women With Polycystic Ovary Syndrome and Insulin Resistance: a Randomized Controlled Trial

Ran2015Enrolled342Registered outcomes12Posted comparisons0ConditionsInsulin Resistance, Polycystic Ovary SyndromeArmsMetformin, placebo metformin, sham acupuncture, true acupuncture
PMID 21950959PMID 18364705PMID 12243370PMID 11602624PMID 9165656PMID 21121941PMID 22878886PMID 12900694PMID 15833138PMID 16684838PMID 16791967PMID 19420954other papers from this trial
Open the trial in the graph
NCT05952882 phase3unknown statusstarted 2023, after this paper: background citation

Effectiveness of the Combination Liraglutide and Metformin on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With Polycystic Ovarian Syndrome, Obesity and Infertility

Ran2023Enrolled188Registered outcomes60Posted comparisons0ConditionsInfertility, Female, Obesity, Polycystic Ovary SyndromeArmsLiraglutide + metformin, Metformin
PMID 18364705PMID 28681988PMID 19056992PMID 31229399PMID 29703793PMID 19841045PMID 31733195PMID 24362411PMID 14688154PMID 17980364PMID 18068166PMID 22767467other papers from this trial
Open the trial in the graph
NCT06064669 narecruitingstarted 2024, after this paper: background citation

Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus: a Multicenter Double-blind Placebo Controlled Randomized Trial

Ran2024Enrolled988Registered outcomes26Posted comparisons0ConditionsIn-Vitro Fertilization, Metformin, PrediabetesArmsMetformin pretreatment before endometrial preparation for frozen embryo transfer, Metformin pretreatment before ovarian stimulation, Placebo pretreatment before endometrial preparation for frozen embryo transfer, Placebo pretreatment before ovarian stimulation
PMID 34281467PMID 25945500PMID 29045765PMID 18826999PMID 11832527PMID 36396532PMID 36285403PMID 35151523PMID 34506996PMID 34461950PMID 34330423PMID 34182954other papers from this trial
Open the trial in the graph
NCT03362918 nacompletednot on this mapstarted 2018, after this paper: background citation

The Impact of Continuous Aerobic Exercise and High-Intensity Interval Training on Reproductive Outcomes in Polycystic Ovary Syndrome: A Pilot Randomized Controlled Trial.

TypeinterventionalSponsorUniversity of CalgaryRan2018 to 2020Enrolled60ConditionsPolycystic Ovary SyndromeArmsHigh Intensity Interval Training, Continuous Aerobic Exercise Training
NCT05973175 unknown statusnot on this mapstarted 2023, after this paper: background citation

The RolE oF Androgen Excess in MUscle Energy MetaboLism in Women With PolyCystic Ovary Syndrome (The REFUEL PCOS) Study 1

TypeobservationalSponsorRoyal College of Surgeons, IrelandRan2023 to 2025Enrolled40ConditionsPolycystic Ovary Syndrome
NCT06629883 nacompletednot on this mapstarted 2022, after this paper: background citation

Personalized Resistance Training with Peer Support for Women with PCOS Using a Smart Home Video Device: Feasibility Study Guided by Self-Determination Theory

TypeinterventionalSponsorUniversity of South CarolinaRan2022 to 2023Enrolled10ConditionsPolycystic Ovary Syndrome (PCOS)ArmsREPS w/BANDS
3 · Its place in the literature

Who cites it

690 citing papers in PubMed, 17 syntheses or guidelines pooled it, 1,858 citations in OpenAlex.

  1. Pooled it
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  3. Guideline
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  8. Guideline
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630 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Richard S Legro8401 Connecticut Avenue, Suite 900, Chevy Chase, Maryland 20815. govt-prof@endocrine.org.
Silva A Arslanian
David A Ehrmann
Kathleen M Hoeger
M Hassan Murad
Renato Pasquali
Corrine K Welt
Endocrine Society
Harvard University Press · USMayo Clinic · USPennsylvania State University · USPoliclinico S.Orsola-Malpighi · ITUniversity of Chicago · USUniversity of Pittsburgh · USUniversity of Rochester · US

Funding

TRANSGENIC COREP60DK020595 · UNIVERSITY OF CHICAGO · 1985 to 2005
$11.9M
Physiology CoreP30DK020595 · UNIVERSITY OF CHICAGO · 2025 to 2025
$1.4M
NICHD NIH HHS R01 HD065029NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P60 DK020595
6 · The paper itself

Abstract

objectiveThe aim was to formulate practice guidelines for the diagnosis and treatment of polycystic ovary syndrome (PCOS).

participantsAn Endocrine Society-appointed Task Force of experts, a methodologist, and a medical writer developed the guideline. EVIDENCE: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence. CONSENSUS PROCESS: One group meeting, several conference calls, and e-mail communications enabled consensus. Committees and members of The Endocrine Society and the European Society of Endocrinology reviewed and commented on preliminary drafts of these guidelines. Two systematic reviews were conducted to summarize supporting evidence.

conclusionsWe suggest using the Rotterdam criteria for diagnosing PCOS (presence of two of the following criteria: androgen excess, ovulatory dysfunction, or polycystic ovaries). Establishing a diagnosis of PCOS is problematic in adolescents and menopausal women. Hyperandrogenism is central to the presentation in adolescents, whereas there is no consistent phenotype in postmenopausal women. Evaluation of women with PCOS should exclude alternate androgen-excess disorders and risk factors for endometrial cancer, mood disorders, obstructive sleep apnea, diabetes, and cardiovascular disease. Hormonal contraceptives are the first-line management for menstrual abnormalities and hirsutism/acne in PCOS. Clomiphene is currently the first-line therapy for infertility; metformin is beneficial for metabolic/glycemic abnormalities and for improving menstrual irregularities, but it has limited or no benefit in treating hirsutism, acne, or infertility. Hormonal contraceptives and metformin are the treatment options in adolescents with PCOS. The role of weight loss in improving PCOS status per se is uncertain, but lifestyle intervention is beneficial in overweight/obese patients for other health benefits. Thiazolidinediones have an unfavorable risk-benefit ratio overall, and statins require further study.

Indexed as

Evidence-Based MedicineAdolescentAdultAge FactorsFemaleHumansMiddle AgedPolycystic Ovary SyndromeSocieties, Scientific

Identifiers

PMID24151290
PMCPMC5399492
OpenAlexW2120973019

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.