← Statins × quality of life & behaviour

SynthesisBMC medicine2014

Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis.

Ana Filipa Macedo et al.PubMed ↗Full text ↗Publisher ↗

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with lower quality of life & behaviour

−26%−38% to −13%

Bigger than 6 in 10 on the map

As reported

OR 0.74, 95% CI 0.62–0.87

Correlation · may be no link

No clear link with quality of life & behaviour

−8%−19% to +3%

Bigger than 2 in 10 on the map

As reported

OR 0.92, 95% CI 0.81–1.03

Correlation · may be no link

No clear link with quality of life & behaviour

−8%−17% to +2%

Bigger than 2 in 10 on the map

As reported

OR 0.92, 95% CI 0.83–1.02

+1 more in the walkthrough ↓

Four numbers in the abstract

the abstract, start to end

… higher quality studies (respectively: OR 0.74 (95% CI 0.62 to 0.87); OR 0.92 (95% CI 0.81 to 1.03); OR 0.97 (95% CI 0.88 to 1.05); OR 0.92 (95% CI 0.83 to 1.02)); and …

← favours treatmentfavours comparator →
could be chance
Quality of life & behaviour
OR 0.740.62–0.87
Quality of life & behaviour
OR 0.920.81–1.03
Quality of life & behaviour
OR 0.920.83–1.02
Quality of life & behaviour
OR 0.970.88–1.05
StatinsQuality of life & behaviour
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2 trials

NCT050722751,000 enrolled2023NCT0517565110,000 enrolled2023
Full record →Abstract, authors, funding and every citing paper · PMID 24655568