SynthesisTransplantation2014
Effects of obesity on kidney transplantation outcomes: a systematic review and meta-analysis.
Synthesis in Transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 70 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Tolerance of Liraglutide for Weight Loss in Obese Type 2 Diabetic Hemodialysis Patients
Effect of Plant-based Diet on Cardiometabolic and Inflammatory Parameters in Kidney Transplant Recipients
Who cites it
70 citing papers in PubMed, 4 syntheses or guidelines pooled it, 187 citations in OpenAlex.
- Current Evidence on Dietary Factors and Kidney Allograft Function in Kidney Transplant Recipients: A Systematic Review.Current medicinal chemistry · 2024Pooled it
- Management of obesity in kidney transplant candidates and recipients: A clinical practice guideline by the DESCARTES Working Group of ERA.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Guideline
- Pooled it
- Body mass index and outcome in renal transplant recipients: a systematic review and meta-analysis.BMC medicine · 2015Pooled it
- Trial
- Obesity is associated with a higher incidence of rejection in patients on belatacept: A pooled analysis from the BENEFIT/BENEFIT-EXT clinical trials.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Trial
- Trial
- Bariatric Surgery as a Bridge to Kidney Transplantation in Patients with Obesity and Advanced Chronic Kidney Disease or End-Stage Renal Disease: A Systematic Review.Obesity surgery · 2026Review
- Kidney transplantation in obese Black patients: Strategies to improve access and outcomes.World journal of nephrology · 2026Review
- Obesity and Its Clinical Implications in End-Stage Kidney Disease.Medicina (Kaunas, Lithuania) · 2026Review
- Association of Myosteatosis and of Graft Loss after Kidney Transplantation: An International Observational Study.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- The obese transplant organ recipient: experimental and clinical evidence for tailored immunosuppression.Transplant international : official journal of the European Society for Organ Transplantation · 2026Review
- Effects of the pretransplant obesity on kidney transplant outcomes in Korea: a nationwide cohort study.BMC nephrology · 2025Article
- Am I on the list? Clinician-reported factors for kidney transplantation non-waitlisting among Aboriginal and Torres Strait Islander people with kidney failure: a cross-sectional study.The Medical journal of Australia · 2025Observational
- Investigating the controversial link between pediatric obesity and graft survival in kidney transplantation.World journal of nephrology · 2025Article
- Combined Body Mass Index and Body Surface Area to Predict Post Kidney Transplant Outcomes in Patients With Obesity.Transplantation direct · 2025Article
- Postkidney Transplant Delayed Graft Function Outcomes Are Not Worsened by Deceased Donor Type.Clinical transplantation · 2025Article
- Use of Cross-Sectional Imaging Body Composition Assessment to Predict Pancreas Transplant Outcomes.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Sarcopenic obesity is associated with adverse outcomes after kidney transplantation: a retrospective cohort study.International urology and nephrology · 2024Article
- Open Renal Transplantation in Obese Patients: A Correlation Study between BMI and Early and Late Complications with Implementation of a Prognostic Risk Score.Life (Basel, Switzerland) · 2024Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effects of obesity on outcomes reported after kidney transplantation have been controversial. The purpose of this systematic review and meta-analysis was to elucidate this issue.
methodsMEDLINE, EMBASE, Cochrane Library, and gray literature were searched up to August 6, 2013. Studies that compared obese and nonobese patients who underwent kidney transplantation and evaluated one of these outcomes-delayed graft function (DGF), acute rejection, graft or patient survival at 1 or 5 years after transplantation, or death by cardiovascular disease (CVD)-were included. Two independent reviewers extracted the data and assessed the quality of the studies.
resultsFrom 1,973 articles retrieved, 21 studies (9,296 patients) were included. Obesity was associated with DGF (relative risk, 1.41; 95% confidence interval, 1.26-1.57; I=8%; Pheterogeneity=0.36), but not with acute rejection. Graft loss and death were associated with obesity only in the analysis of studies that evaluated patients who received a kidney graft before year 2000. No association of obesity with graft loss and death was found in the analysis of studies that evaluated patients who received a kidney graft after year 2000. Death by CVD was associated with obesity (relative risk, 2.07; 95% confidence interval, 1.17-3.64; I=0%; Pheterogeneity=0.59); however, most studies included in this analysis evaluated patients who received a kidney graft after year 2000.
conclusionIn conclusion, obese patients have increased risk for DGF. In the past years, obesity was a risk factor for graft loss, death by CVD, and all-cause mortality. However, for the obese transplanted patient today, the graft and patient survival is the same as that of the nonobese patient.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.