GLP-1 receptor agonists × glycemic control

TrialDiabetes care2009

Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study.

Michael Nauck et al.PubMed ↗Full text ↗Publisher ↗

  • 1.8 mg liraglutidelooks good hereLower A1C values, no range given, lower body weight, no range given.No ranges given.
  • 0.6 mg liraglutidelooks good hereLower A1C values, no range given.No ranges given.

What the trial testedas reported · 1,091 people · 2009

No range given

Reported lower A1C values, no range given

−1.00percentage points

1.8 mg liraglutide vs placebo

As reported

difference −1.00 %, no interval

No range given

Reported lower A1C values, no range given

−0.70percentage points

0.6 mg liraglutide vs placebo

As reported

difference −0.70 %, no interval

No range given

Reported lower body weight, no range given

−2.80kg

1.8 mg liraglutide vs glimepiride

As reported

difference −2.80 kg, no interval

Who was studied, and how

1,091people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

1.8 mg liraglutide
placebo

Reported lower A1C values, no range given−1.00

randomised

The trial randomly assignedassigned by chance

0.6 mg liraglutide
placebo

Reported lower A1C values, no range given−0.70

randomised

the abstract, start to end

A1C values were significantly reduced in all liraglutide groups versus the placebo group (P < 0.0001) with mean decreases of 1.0% for 1.8 mg liraglutide, 1.2 mg liraglutide, and glimepiride and 0.7% for 0.6 mg liraglutide and an

decreased in all liraglutide groups (1.8-2.8 kg) compared with an increase

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
A1C values1.8 mg liraglutide vs placebo
−1.00
A1C values0.6 mg liraglutide vs placebo
−0.70
Body weight1.8 mg liraglutide vs glimepiride
−2.80
GLP-1 receptor agonistsGlycemic controlBody weight & composition

GLP-1 receptor agonists × glycemic controlhelps?replicated

unlikelylikely
0.910.91 without it
← favours treatmentfavours comparator →
this paperthis papermore certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 18931095