GLP-1 receptor agonists × glycemic control

TrialJournal of diabetes investigation2016

Liraglutide is effective and well tolerated in combination with an oral antidiabetic drug in Japanese patients with type 2 diabetes: A randomized, 52-week, open-label, parallel-group trial.

Kohei Kaku et al.PubMed ↗Full text ↗Publisher ↗

  • Pretrial OAD in combination with liraglutide 0.9 mg/daylooks good hereLower long-term blood sugar, lower fasting blood sugar.Randomised, small.

What the trial testedrandomised · 360 people · 2016

Randomised vs pretrial OAD in combination with an additional OAD

Probably lowered long-term blood sugar

−0.27percentage points−0.44 to −0.09

pretrial OAD in combination with liraglutide 0.9 mg/day vs pretrial OAD in combination with an additional OAD

As reported

difference −0.27 %, 95% CI −0.44 to −0.09 · the paper's word: glycosylated hemoglobin

Randomised vs pretrial OAD in combination with an additional OAD

Probably lowered fasting blood sugar

−5.47mg/dL−10.8 to −0.10

pretrial OAD in combination with liraglutide 0.9 mg/day vs pretrial OAD in combination with an additional OAD

As reported

difference −5.47 mg/dL, 95% CI −10.8 to −0.10 · the paper's word: fasting plasma glucose levels

Who was studied, and how

363people in the A 52-week, Multi-centre, Open-labelled, Randomised trial, from 2012
360of them with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

pretrial OAD in combination with liraglutide 0.9 mg/day
pretrial OAD in combination with an additional OAD

Probably lowered long-term blood sugar−0.27

Probably lowered fasting blood sugar−5.47

randomised

the abstract, start to end

[estimated mean treatment difference -0.27% (95% confidence interval (CI) -0.44, -0.09; P = 0.0026)]; reductions in mean fasting plasma glucose levels were also greater with liraglutide [estimated mean difference -5.47 mg/dL (-0.30 mmol/L; 95% CI:

← favours treatmentfavours comparator →
could be chance
Glycosylated hemoglobinpretrial OAD in combination with liraglutide 0.9 mg/day vs pretrial OAD in combination with an additional OAD
−0.27−0.44 to −0.09
Fasting plasma glucose levelspretrial OAD in combination with liraglutide 0.9 mg/day vs pretrial OAD in combination with an additional OAD
−5.47−10.8 to −0.10
GLP-1 receptor agonistsGlycemic control
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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 26816604