← GLP-1 receptor agonists × glycemic control

SynthesisMedicine2017

Efficacy and safety of liraglutide versus sitagliptin both in combination with metformin in patients with type 2 diabetes: A systematic review and meta-analysis.

Mingxing Li et al.PubMed ↗Full text ↗Publisher ↗

  • Liraglutide with metformin (1.2 mg and 1.8 mg)looks good hereLower long-term blood sugar.Randomised, large.
  • Liraglutide (1.8 mg)no clear effectLower body weight loss.Nothing cleared the noise.

What the trial testedrandomised · 1,440 people · 2017

Randomised vs sitagliptin combination with metformin

Lowered long-term blood sugar

−0.35−0.51 to −0.20

liraglutide with metformin (1.2 mg and 1.8 mg) vs sitagliptin combination with metformin

As reported

difference −0.35, 95% CI −0.51 to −0.20 · the paper's word: glycosylated hemoglobin (HbA1c)

Not counted

Lowered body weight loss

−1.12−1.54 to −0.70

liraglutide (1.8 mg)

As reported

difference −1.12, 95% CI −1.54 to −0.70

Who was studied, and how

1,440people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

liraglutide with metformin (1.2 mg and 1.8 mg)
sitagliptin combination with metformin

Lowered long-term blood sugar−0.35

randomised

The trial randomly assignedassigned by chance

liraglutide (1.8 mg)
the rest

Lowered body weight loss−1.12

randomised

the abstract, start to end

… hemoglobin (HbA1c) (P < .00001, MD = -0.35, 95% CI -0.51 to -0.20).

… body weight loss (P < .00001, MD = -1.12, 95% CI -1.54 to -0.70).

← favours treatmentfavours comparator →
could be chance
Glycosylated hemoglobin (HbA1c)liraglutide with metformin (1.2 mg and 1.8 mg) vs sitagliptin combination with metformin
−0.35−0.51 to −0.20
Body weight lossliraglutide (1.8 mg)
−1.12−1.54 to −0.70
MetforminGLP-1 receptor agonistsGlycemic controlBody weight & composition
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Full record →Abstract, authors, funding and every citing paper · PMID 28953663