GLP-1 receptor agonists × glycemic control

TrialDiabetes, obesity & metabolism2016

Efficacy and safety of liraglutide compared to sulphonylurea during Ramadan in patients with type 2 diabetes (LIRA-Ramadan): a randomized trial.

S T Azar et al.PubMed ↗Full text ↗Publisher ↗

  • Liraglutidelooks good hereLower body weight, lower long-term blood sugar, no clear effect on fructosamine levels.Randomised, small.

What the trial testedrandomised · 18 people · 2016

Randomised vs sulphonylurea

Probably lowered body weight

−0.54kg−0.94 to −0.14

liraglutide vs sulphonylurea

As reported

difference −0.54 kg, 95% CI −0.94 to −0.14

Randomised vs sulphonylurea

Probably lowered long-term blood sugar

−0.59percentage points−0.79 to −0.38

liraglutide vs sulphonylurea

As reported

difference −0.59 %, 95% CI −0.79 to −0.38 · the paper's word: HbA1c

Range includes no effect

No clear effect on fructosamine levels

+3.51µmol/L−5.26 to +12.3

liraglutide vs sulphonylurea

As reported

difference 3.51 µmol/L, 95% CI −5.26 to 12.3

Who was studied, and how

343people in the Efficacy and Safety of Liraglutide Versus Sulphonylurea Both in Combination With Metformin During Ramadan in Subjects With Type 2 Diabetes trial, from 2014
18of them with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

liraglutide
sulphonylurea

Probably lowered body weight−0.54

Probably lowered long-term blood sugar−0.59

No clear effect on fructosamine levels+3.51

randomised

the abstract, start to end

estimated treatment difference (ETD) 3.51 µmol/L (95% CI: -5.26; 12.28);

during Ramadan with liraglutide (ETD: -0.54 kg; 95% CI: -0.94;-0.14;

led to greater HbA1c reduction [ETD: -0.59% (-6.40 mmol/mol), 95% CI:

← favours treatmentfavours comparator →
could be chance
Fructosamine levelsliraglutide vs sulphonylurea
3.51−5.26 to 12.3
Body weightliraglutide vs sulphonylurea
−0.54−0.94 to −0.14
HbA1cliraglutide vs sulphonylurea
−0.59−0.79 to −0.38
GLP-1 receptor agonistsGlycemic controlBody weight & composition
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26 papers cite it

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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 27376711