GLP-1 receptor agonists × quality of life & behaviour

TrialDiabetes, obesity & metabolism2017

Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity.

John Blundell et al.PubMed ↗Full text ↗Publisher ↗

  • Semaglutidelooks bad hereLower ad libitum energy intake during lunch, no range given, lower total energy intake across all ad libitum meals throughout the day, no range given.No ranges given.

What the trial testedas reported · 30 people · 2017

No range given

Reported lower ad libitum energy intake during lunch, no range given

−1255

semaglutide vs placebo

As reported

difference −1255, no interval

No range given

Reported lower total energy intake across all ad libitum meals throughout the day, no range given

−3036

semaglutide vs placebo

As reported

difference −3036, no interval

+1 more in the walkthrough ↓

Who was studied, and how

30people with obesity, in this paper

The trial randomly assignedassigned by chance

semaglutide
placebo

Reported lower ad libitum energy intake during lunch, no range given−1255

Reported lower total energy intake across all ad libitum meals throughout the day, no range given−3036

randomised

the abstract, start to end

ad libitum energy intake during lunch (-1255 kJ; P  < .0001) and during the subsequent evening meal ( P  = .0401) and snacks ( P  = .0034), resulting in a 24% reduction in total energy intake across all ad libitum meals throughout the day (-3036 kJ; P  < .0001).

from baseline in mean body weight of 5.0 kg, predominantly from body fat

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
Ad libitum energy intake during lunchsemaglutide vs placebo
−1255
Total energy intake across all ad libitum meals throughout the daysemaglutide vs placebo
−3036
Mean body weightsemaglutide vs baseline
−5.00
GLP-1 receptor agonistsBody weight & compositionQuality of life & behaviour

GLP-1 receptor agonists × quality of life & behaviourhelps?mixed

unlikelylikely
0.440.50 without it
← favours comparatorfavours treatment →
this papermore certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 28266779