Evidence mapPaperPMID 25471927Full record

ReviewPharmacoEconomics2015

The Epidemiology of Obesity: A Big Picture.

Adela Hruby, Frank B Hu

5 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in PharmacoEconomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 1,301 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,301citing papers in PubMed, 11 pooled it
29.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07653412 recruitingstarted 2026, after this paper: background citation

Prediction of Response to GLP-1/GIP Receptor Agonists in Obesity Using Genetic Risk Score and SNP Profiling: A Prospective Cohort Study.

Ran2026Enrolled220Registered outcomes1Posted comparisons0ConditionsAnti-obesity Agents, Obesity (Disorder), Precision MedicineArmssemaglutide or tirzepatide
Open the trial in the graph
NCT03491930 nawithdrawnnot on this mapstarted 2018, after this paper: background citation

What is the Effect of a Feedback Device on Weight Loss and Metabolic Measurements in Obese People With the Metabolic Syndrome?

TypeinterventionalSponsorRockefeller UniversityRan2018 to 2018Enrolled0ConditionsWeight Loss, Obesity, Pre-Diabetes, Metabolic SyndromeArmsVA MOVE! Coach app, Telephone Coaching, Standard of Care for weight loss.
NCT04029532 completednot on this mapstarted 2019, after this paper: background citation

Factors Associated With Obesity in Adult Women: Respiratory Exchange Ratio, Heart Rate Variation and Body Image

TypeobservationalSponsorNational Taiwan University HospitalRan2019 to 2020Enrolled121ConditionsObesityArmsRespiratory exchange ratio, Heart rate variability, Body composition, Eating behavior, Physical activity recall
NCT04854317 narecruitingnot on this mapstarted 2020, after this paper: background citation

Endoscopic Gastroplasty for Treatment of Obesity: a Single Centre, Randomized Trial

TypeinterventionalSponsorMater Olbia HospitalRan2020 to 2025Enrolled189ConditionsObesityArmsEndoscopic gastroplasty
NCT06944509 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

RADIQAL Study (Radiation Dose and Image Quality Trial)

TypeinterventionalSponsorPhilips Clinical & Medical Affairs GlobalRan2025 to 2027Enrolled824ConditionsCoronary Artery DiseaseArmstreatment with the Azurion system with Xres5, Azurion with Clairy IQ
3 · Its place in the literature

Who cites it

1,301 citing papers in PubMed, 11 syntheses or guidelines pooled it, 2,898 citations in OpenAlex.

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  4. ProbioticNarra J · 2025
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1,241 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Adela HrubyDepartment of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA, ahruby@hsph.harvard.edu.
Frank B Hu
Harvard University · US

Funding

SIGNAL TRANSDUCTION IN HUMAN ABDOMINAL AND GLUTEOFEMORAL ADIPOCYTESP30DK046200 · TUFTS MEDICAL CENTER · 1992 to 2005
$5.3M
DIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASER01HL060712 · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · 1998 to 2005
$763k
NCI NIH HHS U54 CA155626NCI NIH HHS U54CA155626NHLBI NIH HHS HL60712NHLBI NIH HHS R01 HL060712NIDDK NIH HHS DK51158NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK46200
6 · The paper itself

Abstract

The epidemic of overweight and obesity presents a major challenge to chronic disease prevention and health across the life course around the world. Fueled by economic growth, industrialization, mechanized transport, urbanization, an increasingly sedentary lifestyle, and a nutritional transition to processed foods and high-calorie diets over the last 30 years, many countries have witnessed the prevalence of obesity in its citizens double and even quadruple. A rising prevalence of childhood obesity, in particular, forebodes a staggering burden of disease in individuals and healthcare systems in the decades to come. A complex, multifactorial disease, with genetic, behavioral, socioeconomic, and environmental origins, obesity raises the risk of debilitating morbidity and mortality. Relying primarily on epidemiologic evidence published within the last decade, this non-exhaustive review discusses the extent of the obesity epidemic, its risk factors-known and novel-, sequelae, and economic impact across the globe.

Indexed as

Age FactorsCost of IllnessFeeding BehaviorHumansNutrition SurveysObesityPrevalenceRisk FactorsSocioeconomic Factors

Identifiers

PMID25471927
PMCPMC4859313
OpenAlexW2066805219

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.