Evidence map›Paper›PMID 25590213›Full record

SynthesisThe Journal of clinical endocrinology and metabolism2015

Clinical review: Drugs commonly associated with weight change: a systematic review and meta-analysis.

Juan Pablo Domecq, Gabriela Prutsky, Aaron Leppin, M Bassam Sonbol, Osama Altayar, Chaitanya Undavalli, Zhen Wang, Tarig Elraiyah, Juan Pablo Brito, Karen F Mauck and 7 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Juan Pablo DomecqKnowledge and Evaluation Research Unit (J.P.D., G.P., A.L., M.B.S., O.A., C.U., Z.W., T.E., J.P.B., K.F.M., M.H.L., N.A., J.W., S.F., V.M.M., M.H.M.), Mayo Clinic, Rochester, Minnesota 55905; Unidad de Conocimiento y Evidencia (J.P.D., G.P., V.M.M.), Universidad Peruana Cayetano Heredia, Lima 31, Peru; and Division of Preventive, Occupational, and Aerospace Medicine (N,A., M.H.M.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (J.P.B., V.M.M.), Division of General Internal Medicine (K.F.M.), and Mayo Clinic Libraries (L.J.P.), Mayo Clinic, Rochester, Minnesota 55905.
Gabriela Prutsky
Aaron Leppin
M Bassam Sonbol
Osama Altayar
Chaitanya Undavalli
Zhen Wang
Tarig Elraiyah
Juan Pablo Brito
Karen F Mauck
Mohammed H Lababidi
Larry J Prokop
Noor Asi
Justin Wei
Salman Fidahussein
Victor M Montori
Mohammad Hassan Murad

Funding

NCATS NIH HHS UL1 TR000135
6 · The paper itself

Abstract

contextVarious drugs affect body weight as a side effect.

objectiveWe conducted this systematic review and meta-analysis to summarize the evidence about commonly prescribed drugs and their association with weight change. DATA SOURCES: MEDLINE, DARE, and the Cochrane Database of Systematic Reviews were searched to identify published systematic reviews as a source for trials. STUDY SELECTION: We included randomized trials that compared an a priori selected list of drugs to placebo and measured weight change. DATA EXTRACTION: We extracted data in duplicate and assessed the methodological quality using the Cochrane risk of bias tool.

resultsWe included 257 randomized trials (54 different drugs; 84 696 patients enrolled). Weight gain was associated with the use of amitriptyline (1.8 kg), mirtazapine (1.5 kg), olanzapine (2.4 kg), quetiapine (1.1 kg), risperidone (0.8 kg), gabapentin (2.2 kg), tolbutamide (2.8 kg), pioglitazone (2.6 kg), glimepiride (2.1 kg), gliclazide (1.8 kg), glyburide (2.6 kg), glipizide (2.2 kg), sitagliptin (0.55 kg), and nateglinide (0.3 kg). Weight loss was associated with the use of metformin (1.1 kg), acarbose (0.4 kg), miglitol (0.7 kg), pramlintide (2.3 kg), liraglutide (1.7 kg), exenatide (1.2 kg), zonisamide (7.7 kg), topiramate (3.8 kg), bupropion (1.3 kg), and fluoxetine (1.3 kg). For many other remaining drugs (including antihypertensives and antihistamines), the weight change was either statistically nonsignificant or supported by very low-quality evidence.

conclusionsSeveral drugs are associated with weight change of varying magnitude. Data are provided to guide the choice of drug when several options exist and institute preemptive weight loss strategies when obesogenic drugs are prescribed.

Indexed as

Antipsychotic AgentsBody WeightHumansHypoglycemic AgentsWeight GainWeight LossAntipsychotic AgentsHypoglycemic Agents

Identifiers

PMID25590213
PMCPMC5393509

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.