Diet, exercise & lifestyle × body weight & composition

TrialAnnals of internal medicine2019

Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study.

John W Apolzan et al.PubMed ↗Full text ↗Publisher ↗

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maintained between years 6 and 15 was 6.2% (95% CI, 5.2% to 7.2%) in the metformin group, 3.7% (CI, 3.1% to 4.4%) in the ILS group, and 2.8% (CI, 1.3% to 4.4%) in the

← favours treatmentfavours comparator →
could be chance
Mean weight loss relative to baseline that was maintained between years 6 and 15metformin vs baseline weight, in participants who lost at least 5% of baseline weight in the first year
−6.20−7.20 to −5.20
Mean weight loss relative to baseline that was maintained between years 6 and 15intensive lifestyle intervention (ILS) vs baseline weight, in participants who lost at least 5% of baseline weight in the first year
−3.70−4.40 to −3.10
Mean weight loss relative to baseline that was maintained between years 6 and 15placebo vs baseline weight, in participants who lost at least 5% of baseline weight in the first year
−2.80−4.40 to −1.30
MetforminDiet, exercise & lifestyleBody weight & composition
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