Evidence map›Paper›PMID 25673413›Full record

SynthesisNature2015

Genetic studies of body mass index yield new insights for obesity biology.

Adam E Locke, Bratati Kahali, Sonja I Berndt, Anne E Justice, Tune H Pers, Felix R Day, Corey Powell, Sailaja Vedantam, Martin L Buchkovich, Jian Yang and 486 more

3 registry-linked trialsOpen access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 2,618 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2,618citing papers in PubMed, 8 pooled it
388.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07653412 recruitingstarted 2026, after this paper: background citation

Prediction of Response to GLP-1/GIP Receptor Agonists in Obesity Using Genetic Risk Score and SNP Profiling: A Prospective Cohort Study.

Ran2026Enrolled220Registered outcomes1Posted comparisons0ConditionsAnti-obesity Agents, Obesity (Disorder), Precision MedicineArmssemaglutide or tirzepatide
PMID 33567185PMID 35658024PMID 30124842PMID 30104762PMID 25471927PMID 17434869PMID 16415884other papers from this trial
Open the trial in the graph
NCT03766191 nacompletednot on this mapstarted 2019, after this paper: background citation

The Relation of Genetic Factors, Food Cues, and Self-Regulation With Excess Consumption and Adiposity in Children

TypeinterventionalSponsorTrustees of Dartmouth CollegeRan2019 to 2024Enrolled189ConditionsChildhood ObesityArmsFood Ads, Non-food Ads
NCT04959318 nacompletednot on this mapstarted 2019, after this paper: background citation

Precision Nutrition Impact on Health-Related Behavior Change in Active Duty Service Members

TypeinterventionalSponsorMadigan Army Medical CenterRan2019 to 2021Enrolled138ConditionsMetabolic SyndromeArmsProfessional nutrition counseling, No professional nutrition counseling
3 · Its place in the literature

Who cites it

2,618 citing papers in PubMed, 8 syntheses or guidelines pooled it, 4,845 citations in OpenAlex.

  1. Pooled it
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  6. Polygenic Risk and Nutrient Intake Interactions on Obesity Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Pooled it
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  17. New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
    Article
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2,558 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

496 authors at 20 institutions in 33 countries.

Adam E Locke *Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Bratati Kahali *Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Sonja I Berndt *Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Anne E Justice *Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Tune H Pers *Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Felix R DayMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Corey PowellDepartment of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Sailaja VedantamDivisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Martin L BuchkovichDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Jian YangQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Damien C Croteau-ChonkaDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Tonu EskoDivisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Tove FallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Teresa FerreiraWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Stefan GustafssonScience for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
Zoltán KutalikInstitute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne 1010, Switzerland.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Reedik MägiEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Joshua C RandallWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Thomas W WinklerDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
Andrew R WoodGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Tsegaselassie WorkalemahuDepartment of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA.
Jennifer A SmithDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Jing Hua ZhaoMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Wei ZhaoDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Jin ChenDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
Rudolf FehrmannDepartment of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Åsa K HedmanScience for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
Juha KarjalainenDepartment of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Ellen M SchmidtDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Devin AbsherHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Najaf AminGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
Denise AndersonTelethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia 6008, Australia.
Marian BeekmanNetherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Jennifer L BoltonCentre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
Jennifer L Bragg-GreshamCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Steven BuyskeDepartment of Statistics & Biostatistics, Rutgers University, Piscataway, New Jersey 08854, USA.
Ayse DemirkanGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
Guohong DengEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Georg B EhretCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark.
Mary F FeitosaDepartment of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Krista FischerEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Anuj GoelWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Jian GongDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Anne U JacksonCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Stavroula KanoniWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Marcus E KleberVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.
Kati KristianssonNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Unhee LimEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA.
Vaneet LotayThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Irene Mateo LeachDepartment of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Carolina Medina-GomezNetherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Sarah E MedlandQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Michael A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
Cameron D PalmerDivisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Dorota PaskoGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Sonali PechlivanisInstitute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany.
Marjolein J PetersNetherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Inga ProkopenkoWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Dmitry ShunginDepartment of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.
Alena StančákováUniversity of Eastern Finland, FI-70210 Kuopio, Finland.
Rona J StrawbridgeAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Yun Ju SungDivision of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA.
Alexander TeumerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Sander W van der LaanExperimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Jessica van SettenDepartment of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Jana V Van Vliet-OstaptchoukDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Zhaoming WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Loïc YengoCNRS UMR 8199, F-59019 Lille, France.
Weihua ZhangEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Aaron IsaacsGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
Eva AlbrechtInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Johan ÄrnlövScience for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
Gillian M ArscottPathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.
Antony P AttwoodDepartment of Haematology, University of Cambridge, Cambridge CB2 0PT, UK.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze (ASF), 50125 Florence, Italy.
Amy BarrettOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
Isabelita N BasUSC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines.
Claire BellisDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA.
Amanda J BennettOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
Christian BerneDepartment of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala 75185, Sweden.
Roza BlagievaDivision of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany.
Matthias BlüherIntegrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
Stefan BöhringerNetherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Lori L BonnycastleMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Yvonne BöttcherIntegrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
Heather A BoydDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark.
Marcel BruinenbergLifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Ida H CaspersenDepartment of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Yii-Der Ida ChenDepartment of Pediatrics, University of California Los Angeles, Torrance, California 90502, USA.
Robert ClarkeClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
E Warwick DawDepartment of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Anton J M de CraenDepartment of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Graciela DelgadoVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.
Maria DimitriouDepartment of Dietetics-Nutrition, Harokopio University, 17671 Athens, Greece.
Alex S F DoneyMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Niina EklundNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Karol EstradaBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Elodie EuryCNRS UMR 8199, F-59019 Lille, France.
Lasse FolkersenAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Ross M FraserCentre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
Melissa E GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA.
Frank GellerDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark.
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala 75185, Sweden.
Bruna GiganteDivision of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden.
Alan S GoKaiser Permanente, Division of Research, Oakland, California 94612, USA.
Alain GolayService of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva CH-1211, Switzerland.
Alison H GoodallDepartment of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.
Scott D GordonQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Mathias GorskiDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
Hans-Jörgen GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, D-17475 Greifswald, Germany.
Harald GrallertInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Tanja B GrammerVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.
Jürgen GräßlerDepartment of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
Henrik GrönbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Christopher J GrovesOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
Gaëlle GustoInstitut inter Régional pour la Santé, Synergies, F-37520 La Riche, France.
Jeffrey HaesslerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Toomas HallerEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Goran HallmansDepartment of Public Health and Clinical Medicine, Unit of Nutritional Research, Umeå University, Umeå 90187, Sweden.
Catharina A HartmanDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands.
Maija HassinenKuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Nancy L Heard-CostaNational Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Quinta HelmerNetherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Christian HengstenbergDeutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.
Oddgeir HolmenDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway.
Jouke-Jan HottengaBiological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands.
Alan L JamesDepartment of Pulmonary Physiology and Sleep Medicine, Nedlands, Western Australia 6009, Australia.
Janina M JeffThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Åsa JohanssonUppsala University, Department of Immunology, Genetics, Pathology, SciLifeLab, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden.
Jennifer JolleyDepartment of Haematology, University of Cambridge, Cambridge CB2 0PT, UK.
Thorhildur JuliusdottirWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Leena KinnunenNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Wolfgang KoenigDepartment of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany.
Markku KoskenvuoHjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland.
Wolfgang KratzerDepartment of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany.
Jaana LaitinenFinnish Institute of Occupational Health, FI-90100 Oulu, Finland.
Claudia LaminaDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria.
Karin LeanderDivision of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden.
Nanette R LeeUSC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines.
Peter LichtnerInstitute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Lars LindDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
Jaana LindströmNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Ken Sin LoMontreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.
Stéphane LobbensCNRS UMR 8199, F-59019 Lille, France.
Roberto LorbeerInstitute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.
Yingchang LuThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
François MachCardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Wendy L McArdleSchool of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Stela McLachlanCentre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
Cristina MenniDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Sigrun MergerDivision of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany.
Evelin MihailovEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Lili MilaniEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Alireza MoayyeriDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Keri L MondaDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Mario A MorkenMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Antonella MulasIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy.
Gabriele MüllerCenter for Evidence-based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Arthur W MuskDepartment of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia.
Ramaiah NagarajaLaboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA.
Markus M NöthenDepartment of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany.
Ilja M NolteDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Stefan PilzDepartment of Epidemiology and Biostatistics, Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University Medical Center, 1081BT Amsterdam, The Netherlands.
Nigel W RaynerWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Frida RenstromDepartment of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.
Rainer RettigInstitute of Physiology, University Medicine Greifswald, D-17495 Karlsburg, Germany.
Janina S RiedInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Stephan RipkeAnalytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
Neil R RobertsonWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.
Serena SannaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy.
Hubert ScharnaglClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.
Salome ScholtensLifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Fredrick R SchumacherDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
William R ScottEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Thomas SeufferleinDepartment of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany.
Jianxin ShiNational Cancer Institute, Bethesda, Maryland 20892, USA.
Albert Vernon SmithIcelandic Heart Association, Kopavogur 201, Iceland.
Joanna SmolonskaDepartment of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Alice V StantonMolecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.
Valgerdur SteinthorsdottirdeCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.
Kathleen StirrupsWellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Heather M StringhamCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Johan SundströmDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
Morris A SwertzDepartment of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Amy J SwiftMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Ann-Christine SyvänenScience for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
Sian-Tsung TanEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Bamidele O TayoDepartment of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 61053, USA.
Barbara ThorandGerman Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
Gudmar ThorleifssondeCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.
Jonathan P TyrerDepartment of Oncology, University of Cambridge, Cambridge CB2 0QQ, UK.
Hae-Won UhNetherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Liesbeth VandenputCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.
Frank C VerhulstDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Centre, 3000 CB Rotterdam, The Netherlands.
Sita H VermeulenDepartment for Health Evidence, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
Niek VerweijDepartment of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Judith M VonkDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Lindsay L WaiteHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Helen R WarrenDepartment of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Dawn WaterworthGenetics, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA.
Michael N WeedonGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Lynne R WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA.
Christina WillenborgGerman Center for Cardiovascular Research, partner site Hamburg/Lubeck/Kiel, 23562 Lubeck, Germany.
Tom WilsgaardDepartment of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway.
Mary K WojczynskiDepartment of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Andrew WongMRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK.
Alan F WrightMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Qunyuan ZhangDepartment of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
LifeLines Cohort Study
Eoin P BrennanDiabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland.
Murim ChoiDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Zari DastaniLady Davis Institute, Departments of Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal, Québec H3T1E2, Canada.
Alexander W DrongWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Per ErikssonAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Anders Franco-CerecedaCardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden.
Jesper R GådinAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Ali G GharaviDepartment of Medicine, Columbia University College of Physicians and Surgeons, New York 10032, USA.
Michael E GoddardBiosciences Research Division, Department of Primary Industries, Victoria 3083, Australia.
Robert E HandsakerBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Jinyan HuangDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Fredrik KarpeOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
Sekar KathiresanBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Sarah KeildsonWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Krzysztof KirylukDepartment of Medicine, Columbia University College of Physicians and Surgeons, New York 10032, USA.
Michiaki KuboLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
Jong-Young LeeCenter for Genome Science, National Institute of Health, Chungcheongbuk-do, Chungbuk 363-951, Republic of Korea.
Liming LiangDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Richard P LiftonDepartment of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, New Haven, Connecticut 06520, USA.
Baoshan MaDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Steven A McCarrollBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Amy J McKnightNephrology Research, Centre for Public Health, Queen's University of Belfast, Belfast, County Down BT9 7AB, UK.
Josine L MinSchool of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Miriam F MoffattNational Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
Grant W MontgomeryQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Joanne M MurabitoNational Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.
George NicholsonDepartment of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.
Dale R NyholtQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Yukinori OkadaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
John R B PerryWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Rajkumar DorajooGenome Institute of Singapore, Agency for Science, Technology and Research, 138672 Singapore.
Eva ReinmaaEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Rany M SalemDivisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Niina SandholmDepartment of Biomedical Engineering and Computational Science, Aalto University School of Science, Helsinki FI-00076, Finland.
Robert A ScottMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Lisette StolkNetherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Atsushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
Toshihiro TanakaDepartment of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan.
Ferdinand M van 't HooftAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Anna A E VinkhuyzenQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Harm-Jan WestraDepartment of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Wei ZhengDivision of Epidemiology, Department of Medicine; Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37075, USA.
Krina T ZondervanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
ADIPOGen Consortium
AGEN-BMI Working Group
CARDIOGRAMplusC4D Consortium
CKDGen Consortium
GLGC
ICBP
MAGIC Investigators
MuTHER Consortium
MIGen Consortium
PAGE Consortium
ReproGen Consortium
GENIE Consortium
International Endogene Consortium
Andrew C HeathDepartment of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Dominique ArveilerDepartment of Epidemiology and Public Health, EA3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France.
Stephan J L BakkerDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
John BeilbyPathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.
Richard N BergmanCedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, California 90048, USA.
John BlangeroDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA.
Pascal BovetInstitute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1010 Lausanne, Switzerland.
Harry CampbellCentre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
Mark J CaulfieldDepartment of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Giancarlo CesanaUniversity of Milano, Bicocca, 20126, Italy.
Aravinda ChakravartiCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.
Peter S ChinesMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Francis S CollinsMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Dana C CrawfordCenter for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA.
L Adrienne CupplesNational Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Daniele CusiDepartment of Health Sciences, University of Milano, I 20142, Italy.
John DaneshDepartment of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Ulf de FaireDivision of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden.
Hester M den RuijterExperimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Anna F DominiczakInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
Raimund ErbelClinic of Cardiology, West-German Heart Centre, University Hospital Essen, 45147 Essen, Germany.
Jeanette ErdmannGerman Center for Cardiovascular Research, partner site Hamburg/Lubeck/Kiel, 23562 Lubeck, Germany.
Johan G ErikssonNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Martin FarrallWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Stephan B FelixDepartment of Internal Medicine B, University Medicine Greifswald, D-17475 Greifswald, Germany.
Ele FerranniniDepartment of Internal Medicine, University of Pisa, 56100 Pisa, Italy.
Jean FerrièresDepartment of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, 31400 Toulouse, France.
Ian FordRobertson Center for Biostatistics, University of Glasgow, Glasgow G12 8QQ, UK.
Nita G ForouhiMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Terrence ForresterUWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica.
Oscar H FrancoNetherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Ron T GansevoortDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Pablo V GejmanNorthShore University HealthSystem, Evanston, IL 60201, University of Chicago, Chicago, Illinois, USA.
Christian GiegerInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Omri GottesmanThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur 201, Iceland.
Ulf GyllenstenUppsala University, Department of Immunology, Genetics, Pathology, SciLifeLab, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden.
Alistair S HallLeeds MRC Medical Bioinformatics Centre, University of Leeds, Leeds LS2 9LU, UK.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA.
Andrew T HattersleyInstitute of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK.
Andrew A HicksCenter for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy (affiliated institute of the University of Lübeck, D-23562 Lübeck, Germany).
Lucia A HindorffDivision of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Aroon D HingoraniInstitute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
Albert HofmanNetherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.
G Kees HovinghDepartment of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands.
Steve E HumphriesCentre for Cardiovascular Genetics, Institute Cardiovascular Sciences, University College London, London WC1E 6JJ, UK.
Steven C HuntCardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA.
Elina HyppönenSansom Institute for Health Research, University of South Australia, Adelaide 5000, South Australia, Australia.
Thomas IlligResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Kevin B JacobsDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
Karl-Heinz JöckelInstitute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany.
Berit JohansenDepartment of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Pekka JousilahtiNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Antti M JulaNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Jaakko KaprioNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
John J P KasteleinDepartment of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands.
Sirkka M Keinanen-KiukaanniemiInstitute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland.
Lambertus A KiemeneyDepartment for Health Evidence, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
Paul KnektNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Jaspal S KoonerEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Peter KovacsIntegrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
Aldi T KrajaDepartment of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Meena KumariDepartment of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
Johanna KuusistoDepartment of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland.
Timo A LakkaKuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, FI-33520 Tampere, Finland.
Valeriya LyssenkoSteno Diabetes Center A/S, Gentofte DK-2820, Denmark.
Satu MännistöNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
André MaretteInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada.
Tara C MatiseDepartment of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA.
Colin A McKenzieUWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica.
Barbara McKnightDepartment of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
Frans L MollDepartment of Surgery, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Andrew D MorrisMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Andrew P MorrisEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Jeffrey C MurrayDepartment of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA.
Mari NelisEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Claes OhlssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.
Albertine J OldehinkelDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands.
Ken K OngMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Pamela A F MaddenDepartment of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Gerard PasterkampExperimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
John F PedenIllumina, Inc, Little Chesterford, Cambridge CB10 1XL, UK.
Annette PetersResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Dirkje S PostmaUniversity of Groningen, University Medical Center Groningen, Department of Pulmonary Medicine and Tuberculosis, Groningen, The Netherlands.
Peter P PramstallerCenter for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy (affiliated institute of the University of Lübeck, D-23562 Lübeck, Germany).
Jackie F PriceCentre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
Lu QiChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
D C RaoDepartment of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Treva K RiceDivision of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.
John D RiouxMontreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.
Marylyn D RitchieCenter for Systems Genomics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Igor RudanCentre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
Veikko SalomaaNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.
Jouko SaramiesSouth Carelia Central Hospital, 53130 Lappeenranta, Finland.
Mark A SarzynskiHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
Heribert SchunkertDeutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.
Peter E H SchwarzDepartment of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
Peter SeverInternational Centre for Circulatory Health, Imperial College London, London W2 1PG, UK.
Alan R ShuldinerDivision of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Juha SinisaloHelsinki University Central Hospital Heart and Lung Center, Department of Medicine, Helsinki University Central Hospital, FI-00290 Helsinki, Finland.
Ronald P StolkDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Anke TönjesIntegrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
David-Alexandre TrégouëtSorbonne Universités, UPMC Univ Paris 06, UMR S 1166, F-75013 Paris, France.
Angelo TremblayDepartment of Kinesiology, Laval University, Quebec QC G1V 0A6, Canada.
Elena TremoliDipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano & Centro Cardiologico Monzino, Instituto di Ricovero e Cura a Carattere Scientifico, Milan 20133, Italy.
Jarmo VirtamoNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Marie-Claude VohlInstitute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.
Gérard WaeberDepartment of Internal Medicine, University Hospital (CHUV) and University of Lausanne, Lausanne 1011, Switzerland.
Gonneke WillemsenBiological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands.
Jacqueline C WittemanDepartment of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.
M Carola ZillikensNetherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Linda S AdairDepartment of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Philippe AmouyelInstitut Pasteur de Lille; INSERM, U744; Université de Lille 2; F-59000 Lille, France.
Folkert W AsselbergsInstitute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA.
Murielle BochudInstitute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1010 Lausanne, Switzerland.
Bernhard O BoehmLee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore, 637553 Singapore, Singapore.
Eric BoerwinkleHealth Science Center at Houston, University of Texas, Houston, Texas 77030, USA.
Stefan R BornsteinDepartment of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
Stéphane CauchiCNRS UMR 8199, F-59019 Lille, France.
John C ChambersEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Richard S CooperDepartment of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 61053, USA.
Paul I W de BakkerDepartment of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
George DedoussisDepartment of Dietetics-Nutrition, Harokopio University, 17671 Athens, Greece.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA.
Paul W FranksDepartment of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Philippe FroguelDepartment of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.
Leif C GroopInstitute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Anders HamstenAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Jennie HuiPathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.
David J HunterChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Kristian HveemDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway.
Robert C KaplanAlbert Einstein College of Medicine, Department of Epidemiology and Population Health, Belfer 1306, New York 10461, USA.
Mika KivimakiDepartment of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
Diana KuhMRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK.
Markku LaaksoDepartment of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland.
Yongmei LiuCenter for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Winfried MärzVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.
Mads MelbyeDepartment of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Susanne MoebusInstitute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany.
Patricia B MunroeDepartment of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Inger NjølstadDepartment of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway.
Ben A OostraGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
Colin N A PalmerMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Markus PerolaEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Louis PérusseInstitute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Chris PowerPopulation, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK.
Thomas QuertermousDepartment of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.
Fernando RivadeneiraNetherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Timo E SaaristoFinnish Diabetes Association, Kirjoniementie 15, FI-33680 Tampere, Finland.
Danish SaleheenDepartment of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Naveed SattarBHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.
Eric E SchadtIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10580, USA.
David SchlessingerLaboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA.
P Eline SlagboomNetherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Harold SniederDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Unnur ThorsteinsdottirdeCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.
Michael StumvollIntegrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
Jaakko TuomilehtoNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
André G UitterlindenNetherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Matti UusitupaDepartment of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.
Pim van der HarstDepartment of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Mark WalkerInstitute of Cellular Medicine, Newcastle University, Newcastle NE1 7RU, UK.
Henri WallaschofskiDZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Hugh WatkinsWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA.
H-Erich WichmannInstitute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-85764 Munich, Germany.
James F WilsonCentre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
Pieter ZanenDepartment of Pulmonology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Ingrid B BoreckiDepartment of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Panos DeloukasWellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Caroline S FoxNational Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Iris M HeidDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
Jeffrey R O'ConnellDivision of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
David P StrachanDivision of Population Health Sciences & Education, St George's, University of London, London SW17 0RE, UK.
Kari StefanssondeCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
Gonçalo R AbecasisCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Lude FrankeDepartment of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Mark I McCarthyWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Peter M VisscherQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
André ScheragInstitute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany.
Cristen J WillerDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
Michael BoehnkeCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Cecilia M LindgrenBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Jacques S BeckmannSwiss Institute of Bioinformatics, Lausanne 1015, Switzerland.
Inês BarrosoWellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Erik IngelssonScience for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
Joel N HirschhornDivisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Ruth J F LoosMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Elizabeth K SpeliotesDepartment of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
University Medical Center Groningen · NLBroad Institute · USUppsala University · SECentre for Human Genetics · GBKarolinska Institutet · SEErasmus MC · NLUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · USHarvard University · USUniversity of Cambridge · GBUniversity of Eastern Finland · FIBrigham and Women's Hospital · USQueen Mary University of London · GBWashington University in St. Louis · USCentre National de la Recherche Scientifique · FRdeCODE Genetics (Iceland) · ISUniversitätsmedizin Greifswald · DEHelmholtz Zentrum München · DENational Institutes of Health · USUniversität Ulm · DE

Funding

Health and Retirement Study: Yrs 35-40U01AG009740 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1990 to 2025
$96.8M
University of Hawaii Cancer Center CCSGP30CA071789 · UNIVERSITY OF HAWAII AT MANOA · 1996 to 2025
$13.6M
PROMOTING OPHTHALMIC SCREENING IN MANAGED CAREP60DK020541 · YESHIVA UNIVERSITY · 1986 to 2005
$12.6M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · BOSTON UNIVERSITY MEDICAL CAMPUS · 1985 to 2025
$8.2M
UC DAVIS ALZHEIMERS DISEASE CENTER COREP30AG010129 · UNIVERSITY OF CALIFORNIA DAVIS · 1991 to 2005
$7.1M
Washington University Nutrition Obesity Research CenterP30DK056341 · WASHINGTON UNIVERSITY · 1999 to 2025
$5.7M
Pilot & Feasibility ProgramP30DK063491 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2003 to 2025
$5.4M
Pilot and Feasibility ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 to 2025
$4.9M
Identifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2003 to 2025
$3.6M
Cardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · 1986 to 2025
$2.7M
Predoctoral Training Program in Human GeneticsT32GM007814 · JOHNS HOPKINS UNIVERSITY · 1985 to 2005
$2.4M
NYR-Diabetes Research Center (NYR-DRC)P30DK020541 · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2025 to 2025
$2.4M
British Heart Foundation BHF_FS/14/55/30806British Heart Foundation BHF_RG/08/008/25291British Heart Foundation BHF_RG/08/014/24067British Heart Foundation BHF_RG/10/12/28456British Heart Foundation FS/14/55/30806British Heart Foundation RG/07/008/23674British Heart Foundation RG/08/008/25291British Heart Foundation RG/08/014/24067British Heart Foundation RG/10/12/28456Cancer Research UK 14136Cancer Research UK CRUK_14136Chief Scientist Office CSO_CZB/4/672Chief Scientist Office CSO_CZB/4/710Chief Scientist Office CZB/4/672Chief Scientist Office CZB/4/710Medical Research Council G0100222Medical Research Council G0401527Medical Research Council G0600717Medical Research Council G0601261Medical Research Council G0902037Medical Research Council G1000143Medical Research Council G1000616Medical Research Council G1001799Medical Research Council G19/35Medical Research Council G8802774Medical Research Council G9521010Medical Research Council MC_PC_U127561128Medical Research Council MC_U106179471Medical Research Council MC_U106179472Medical Research Council MC_UP_A100_1003Medical Research Council MC_UU_12012/1Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/4Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MC_UU_12015/5Medical Research Council MC_UU_12019/1Medical Research Council MRC_G0401527Medical Research Council MRC_G0601261Medical Research Council MRC_G1000143Medical Research Council MRC_G1001799Medical Research Council MRC_G9521010Medical Research Council MRC_MC_PC_U127561128Medical Research Council MRC_MC_U106179471Medical Research Council MRC_MC_U106179472Medical Research Council MRC_MC_UP_A100_1003Medical Research Council MRC_MC_UU_12012/1Medical Research Council MRC_MC_UU_12013/1Medical Research Council MRC_MC_UU_12015/1Medical Research Council MRC_MC_UU_12015/2Medical Research Council MRC_MC_UU_12015/5Medical Research Council MRC_MC_UU_12019/1Medical Research Council MRC_MR/K006584/1Medical Research Council MRC_MR/K013351/1Medical Research Council MRC_MR/L003120/1Medical Research Council MRC_MR/N01104X/1Medical Research Council MR/K002414/1Medical Research Council MR/K006584/1Medical Research Council MR/K013351/1Medical Research Council MR/L003120/1Medical Research Council MR/N01104X/1NCATS NIH HHS TL1 TR001066NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001067NCI NIH HHS P30 CA071789NCI NIH HHS U01 CA164930NCI NIH HHS UM1 CA182910NCI NIH HHS UM1 CA182913NHGRI NIH HHS U01 HG004790NHGRI NIH HHS U01 HG004802NHGRI NIH HHS U01 HG007376NHGRI NIH HHS U01 HG007416NHGRI NIH HHS U01 HG007417NHGRI NIH HHS U01 HG007419NHLBI NIH HHS K01 HL116770NHLBI NIH HHS P30 HL107251NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL109946NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01 HL117626NHLBI NIH HHS T32 HL007055NHLBI NIH HHS T32 HL007824NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG025941NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG041517NIA NIH HHS U01 AG009740NIA NIH HHS U01 AG049505NICHD NIH HHS P2C HD050924NIDA NIH HHS R21 DA027040NIDDK NIH HHS K23 DK080145NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK072488NIDDK NIH HHS P60 DK020541NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK078150NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01 DK093757NIDDK NIH HHS U01 DK062370NIGMS NIH HHS P30 GM103341NIGMS NIH HHS R25 GM062459NIGMS NIH HHS T32 GM007814NIGMS NIH HHS T32 GM080178NIMHD NIH HHS P20 MD006899NINDS NIH HHS R01 NS017950Wellcome Trust 084766Wellcome Trust 085235Wellcome Trust 097117Wellcome Trust 098017Wellcome Trust 098381Wellcome Trust 100574Wellcome Trust WT084766Wellcome Trust WT085235Wellcome Trust WT097117Wellcome Trust WT098017Wellcome Trust WT098381Wellcome Trust WT100574
6 · The paper itself

Abstract

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

Indexed as

Body Mass IndexGenome-Wide Association StudyAdipogenesisAdiposityAge FactorsEnergy MetabolismEuropeFemaleGenetic Predisposition to DiseaseGlutamic AcidHumansInsulinInsulin SecretionMaleObesityPolymorphism, Single NucleotideGlutamic AcidInsulin

Identifiers

PMID25673413
PMCPMC4382211
OpenAlexW2039153962

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.