ReviewJournal of geriatric cardiology : JGC2015
Statins for primary cardiovascular prevention in the elderly.
Review in Journal of geriatric cardiology : JGC, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Medications and Prescribing Patterns as Factors Associated with Hospitalizations from Long-Term Care Facilities: A Systematic Review.Drugs & aging · 2018Pooled it
- Association of Statin Use With Disability-Free Survival and Cardiovascular Disease Among Healthy Older Adults.Journal of the American College of Cardiology · 2020Trial
- Targeting Inflammatory Imbalance in Chronic Kidney Disease: Focus on Anti-Inflammatory and Resolution Mediators.International journal of molecular sciences · 2025Review
- Review
- Cardiovascular effect of discontinuing statins for primary prevention at the age of 75 years: a nationwide population-based cohort study in France.European heart journal · 2019 · on this mapObservational
- Changing predictors of statin initiation in US women over two decades.Pharmacoepidemiology and drug safety · 2019Article
- Primary Prevention of Cardiovascular Risk in Octogenarians by Risk Factors Control.Current hypertension reviews · 2019Review
- Projected Real-World Effectiveness of Using Aggressive Low-Density Lipoprotein Cholesterol Targets Among Elderly Statin Users Following Acute Coronary Syndromes in Canada.Journal of the American Heart Association · 2018Observational
- Statin Use and Adverse Effects Among Adults >75 Years of Age: Insights From the Patient and Provider Assessment of Lipid Management (PALM) Registry.Journal of the American Heart Association · 2018Article
- Impact of Aging on the Strength of Cardiovascular Risk Factors: A Longitudinal Study Over 40 Years.Journal of the American Heart Association · 2018Article
- Atherogenic index of plasma is positively associated with the risk of all-cause death in elderly women : A 10-year follow-up.Wiener klinische Wochenschrift · 2017Observational
- Application of the 2014 NICE cholesterol guidelines in the English population: a cross-sectional analysis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2017Article
- Article
- Targeting LDL Cholesterol: Beyond Absolute Goals Toward Personalized Risk.Current cardiology reports · 2017Review
- Patterns and Predictors of Adherence to Statin Therapy Among Older Patients: Protocol for a Systematic Review.JMIR research protocols · 2017Article
- Geroprotectors as a therapeutic strategy for COPD - where are we now?Clinical interventions in aging · 2017Review
- Personalized absolute benefit of statin treatment for primary or secondary prevention of vascular disease in individual elderly patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Early inner retinal thinning and cardiovascular autonomic dysfunction in type 2 diabetes.PloS one · 2017Article
- The effect of adherence to statin therapy on cardiovascular mortality: quantification of unmeasured bias using falsification end-points.BMC public health · 2016Article
- Current and Emerging Uses of Statins in Clinical Therapeutics: A Review.Lipid insights · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The elderly population is increasing worldwide, with subjects > 65 years of age constituting the fastest-growing age group. Furthermore, the elderly face the greatest risk and burden of cardiovascular disease mortality and morbidity. Although elderly patients, particularly those older > 75, have not been well represented in randomized clinical trials evaluating lipid-lowering therapy, the available evidence supporting the use of statin therapy in primary prevention in older individuals is derived mainly from subgroup analyses and post-hoc data. On the other hand, elderly patients often have multiple co-morbidities that require a high number of concurrent medications; this may increase the risk for drug-drug interactions, thereby reducing the potential benefits of statin therapy. The aim of this review was to present the relevant literature regarding statin use in the elderly for their primary cardiovascular disease, with the associated risks and benefits of treatment.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.