Statins × cardiovascular events

Observational studyEuropean heart journal2019

Cardiovascular effect of discontinuing statins for primary prevention at the age of 75 years: a nationwide population-based cohort study in France.

Philippe Giral et al.PubMed ↗Full text ↗Publisher ↗

  • Statin discontinuationlooks bad hereMore any cardiovascular event, more coronary event, more cerebrovascular event.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Statin discontinuation went with more any cardiovascular event

+33%+18% to +50%

statin discontinuation vs continuation

Bigger than 6 in 10 for cardiovascular events

As reported

HR 1.33, 95% CI 1.18–1.50

Correlation, not cause

Statin discontinuation went with more coronary event

+46%+21% to +75%

statin discontinuation vs continuation

Bigger than 7 in 10 for cardiovascular events

As reported

HR 1.46, 95% CI 1.21–1.75

Correlation, not cause

Statin discontinuation went with more cerebrovascular event

+26%+5% to +51%

statin discontinuation vs continuation

Bigger than 5 in 10 for cardiovascular events

As reported

HR 1.26, 95% CI 1.05–1.51

+1 more in the walkthrough ↓

Who was studied, and how

173people with cardiovascular disease, in this paper

Already taking statin discontinuation, or nottheir own situation, not assigned

on statin discontinuation
continuation

Statin discontinuation went with more any cardiovascular event+33%

Statin discontinuation went with more coronary event+46%

Statin discontinuation went with more cerebrovascular event+26%

correlation, not a test

the abstract, start to end

ratios for statin discontinuation were 1.33 [95% confidence interval (CI) 1.18-1.50] (any cardiovascular event), 1.46 (95% CI 1.21-1.75) (coronary event), 1.26 (95% CI 1.05-1.51) (cerebrovascular event), and 1.02 (95% CI 0.74-1.40) (other

← favours treatmentfavours comparator →
could be chance
Any cardiovascular eventstatin discontinuation vs continuation
HR 1.331.18–1.50
Coronary eventstatin discontinuation vs continuation
HR 1.461.21–1.75
Cerebrovascular eventstatin discontinuation vs continuation
HR 1.261.05–1.51
Other vascular eventstatin discontinuation vs continuation
HR 1.020.74–1.40
StatinsCardiovascular events
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