Evidence map›Paper›PMID 26868660›Full record

ReviewLancet (London, England)2016

Management of obesity.

George A Bray, Gema Frühbeck, Donna H Ryan, John P H Wilding

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Lancet (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 445 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
445citing papers in PubMed, 24 pooled it
85.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06287307 phase4not yet recruitingstarted 2024, after this paper: background citation

Semaglutide 2.4mg for Low Responders After Bariatric Surgery

Ran2024Enrolled152Registered outcomes55Posted comparisons0ConditionsObesity, Obesity, Morbid, Weight GainArmsPlacebo, Semaglutide 2.4 MG/0.75 ML Subcutaneous Solution [WEGOVY]
PMID 26887340PMID 33755728PMID 33625476PMID 33567185PMID 30768766PMID 26371721PMID 19370590PMID 29207379PMID 28791623PMID 26641646PMID 25590212PMID 24776071other papers from this trial
Open the trial in the graph
NCT07559643 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Prospective, Randomised Controlled Trial Comparing Weight-based Tinzaparin Versus Weight-based Enoxaparin for Peri-operative Thromboprophylaxis in Patients Undergoing Bariatric Surgery: Evaluation of Anti-Xa Levels and Clinical Outcomes.

TypeinterventionalSponsorUniversity College DublinRan2026 to 2026Enrolled180ConditionsBariatric Surgery, Anti-Xa Activity, VTE (Venous Thromboembolism), Obesity & OverweightArmsAnti-Xa Activity Monitoring, Tinzaparin (Leo), enoxaparin
3 · Its place in the literature

Who cites it

445 citing papers in PubMed, 24 syntheses or guidelines pooled it, 982 citations in OpenAlex.

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  2. Efficacy of Weight-Lowering Agents on Fat Distribution: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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  10. Neutrophils as indicators of obesity-associated inflammation: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
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  14. EPA guidance on lifestyle interventions for adults with severe mental illness: A meta-review of the evidence.European psychiatry : the journal of the Association of European Psychiatrists · 2024
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  20. Acupoint catgut embedding for simple obesity in animal studies: a systematic review and Meta-analysis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023
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385 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

George A BrayPennington Biomedical Research Center/LSU, Baton Rouge, LA, USA. Electronic address: brayga@pbrc.edu.
Gema FrühbeckDepartment of Endocrinology and Nutrition, Clínica Universidad de Navarra, University of Navarra, CIBEROBN, IdiSNA, Spain.
Donna H RyanPennington Biomedical Research Center/LSU, Baton Rouge, LA, USA.
John P H WildingDepartment of Medicine (Obesity) University of Liverpool, Liverpool, UK.
Pennington Biomedical Research Center · USClinica Universidad de Navarra · ESUniversity of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A modern approach to obesity acknowledges the multifactorial determinants of weight gain and the health benefits to be derived from weight loss. Foundational to any weight loss effort is lifestyle change, diet, and increased physical activity. The approach should be a high quality diet to which patients will adhere accompanied by an exercise prescription describing frequency, intensity, type, and time with a minimum of 150 min moderate weekly activity. For patients who struggle with weight loss and who would receive health benefit from weight loss, management of medications that are contributing to weight gain and use of approved medications for chronic weight management along with lifestyle changes are appropriate. Medications approved in the USA or European Union are orlistat, naltrexone/bupropion, and liraglutide; in the USA, lorcaserin and phentermine/topiramate are also available. Surgical management (gastric banding, sleeve gastrectomy, and Roux-en Y gastric bypass) can produce remarkable health improvement and reduce mortality for patients with severe obesity.

Indexed as

Anti-Obesity AgentsBariatric SurgeryDiet, ReducingExercise TherapyHumansObesityRisk Reduction BehaviorTreatment OutcomeWeight LossAnti-Obesity Agents

Identifiers

PMID26868660
OpenAlexW2260747663

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.