Diet, exercise & lifestyle × glycemic control

SynthesisPloS one2017

The Effectiveness of Pharmacological and Non-Pharmacological Interventions for Improving Glycaemic Control in Adults with Severe Mental Illness: A Systematic Review and Meta-Analysis.

Johanna Taylor et al.PubMed ↗Full text ↗Publisher ↗

  • Pharmacological interventionslooks good hereLower fasting blood sugar, no clear effect on long-term blood sugar.Randomised, large.
  • Behavioural interventionslooks good hereLower fasting blood sugar, no clear effect on long-term blood sugar.Randomised, large.

What the trial testedrandomised · 5,147 people · 2017

Randomised vs usual care or placebo

Lowered fasting blood sugar

−0.11mmol/L−0.19 to −0.02

pharmacological interventions vs usual care or placebo

As reported

difference −0.11 mmol/L, 95% CI −0.19 to −0.02 · the paper's word: fasting glucose

Randomised vs usual care or placebo

Lowered fasting blood sugar

−0.28−0.43 to −0.12

behavioural interventions vs usual care or placebo

As reported

difference −0.28, 95% CI −0.43 to −0.12 · the paper's word: fasting glucose

Range includes no effect

No clear effect on long-term blood sugar

−0.03percentage points−0.12 to +0.06

pharmacological interventions vs usual care or placebo

As reported

difference −0.03 %, 95% CI −0.12 to 0.06 · the paper's word: HbA1c

Range includes no effect

No clear effect on long-term blood sugar

+0.18percentage points−0.07 to +0.42

behavioural interventions vs usual care or placebo

As reported

difference 0.18 %, 95% CI −0.07 to 0.42 · the paper's word: HbA1c

Who was studied, and how

5,147people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

pharmacological interventions
usual care or placebo

Lowered fasting blood sugar−0.11

No clear effect on long-term blood sugar−0.03

randomised

The trial randomly assignedassigned by chance

behavioural interventions
usual care or placebo

Lowered fasting blood sugar−0.28

No clear effect on long-term blood sugar+0.18

randomised

the abstract, start to end

pharmacological (mean difference (MD), -0.11mmol/L; 95% confidence interval (CI), [-0.19, -0.02], p = 0.02, n = 2536) and behavioural interventions (MD, -0.28mmol//L; 95% CI, [-0.43, -0.12], p<0.001, n = 956) were effective in lowering fasting glucose, but not HbA1c (pharmacological MD, -0.03%; 95% CI, [-0.12, 0.06], p = 0.52, n = 1515; behavioural MD, 0.18%; 95% CI, [-0.07, 0.42], p =

← favours treatmentfavours comparator →
could be chance
Fasting glucosepharmacological interventions vs usual care or placebo
−0.11−0.19 to −0.02
Fasting glucosebehavioural interventions vs usual care or placebo
−0.28−0.43 to −0.12
HbA1cpharmacological interventions vs usual care or placebo
−0.03−0.12 to 0.06
HbA1cbehavioural interventions vs usual care or placebo
0.18−0.07 to 0.42
Diet, exercise & lifestyleGlycemic control

Diet, exercise & lifestyle × glycemic controlhelps?replicated

unlikelylikely
0.99not counted
← favours treatmentfavours comparator →
more certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 28056018