Metformin × glycemic control

TrialThe Journal of clinical endocrinology and metabolism2017

Effect of Metformin on Vascular Function in Children With Type 1 Diabetes: A 12-Month Randomized Controlled Trial.

Jemma J A Anderson et al.PubMed ↗Publisher ↗

What the trial testedrandomised · 2017

Randomised comparison

Probably raised glycemic control

+1.00percentage points+0.40 to +1.50

As reported

difference 1 %, 95% CI 0.40–1.50

Randomised comparison

Probably raised adverse events & safety

1.6×1.1× to 2.5×

Bigger than 7 in 10 for adverse events & safety

As reported

IRR 1.65, 95% CI 1.08–2.52

Two numbers in the abstract

the abstract, start to end

Metformin had a beneficial effect on HbA1c at 3 months (P = 0.001) and

on metformin (incidence rate ratio 1.65, 95% CI 1.08, 2.52, P = 0.02),

← favours treatmentfavours comparator →
could be chance
Glycemic control
10.40–1.50
Adverse events & safety
IRR 1.651.08–2.52
MetforminGlycemic controlAdverse events & safety

Metformin × glycemic controlhelps?replicated

unlikelylikely
0.840.86 without it

Metformin × adverse events & safetyharms?mixed

unlikelylikely
0.270.21 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 29040598