TrialNature communications2025

Effect of metformin on insulin resistance in adults with type 1 diabetes: a 26-week randomized double-blind clinical trial.

Metformin 1500 mgno clear effectNo clear effect on endogenous glucose production during the low-dose phase of the clamp.Nothing cleared the noise.

What the trial testedas reported · 40 people · 2025

Range includes no effect

+0.20−0.40 to +0.80

metformin 1500 mg vs placebo

As reported

difference 0.2, 95% CI −0.40 to 0.80 · the paper's word: change in endogenous glucose production (EGP) during the low-dose phase of the clamp

40people with type 1 diabetes, in this paper

The trial randomly assignedassigned by chance

metformin 1500 mg

placebo

No clear effect on endogenous glucose production during the low-dose phase of the clamp+0.20

randomised

the abstract, start to end

… and placebo groups (mean difference 0.2 µmol/kg fat-free mass [FFM]/min …

← favours treatmentfavours comparator →

could be chance

Change in endogenous glucose production (EGP) during the low-dose phase of the clampmetformin 1500 mg vs placebo

0.2−0.40 to 0.80

MetforminGlycemic control

Metformin × glycemic controlhelps?replicated

unlikelylikely

0.840.84 without it

← favours treatmentfavours comparator →

this papermore certainless certain

1 / 6

2025

2026

this papercites it