Evidence map›Paper›PMID 29523133›Full record

ReviewReproductive biology and endocrinology : RB&E2018

Obesity as disruptor of the female fertility.

Erica Silvestris, Giovanni de Pergola, Raffaele Rosania, Giuseppe Loverro

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reproductive biology and endocrinology : RB&E, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 290 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
290citing papers in PubMed, 9 pooled it
38.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07242534 phase4recruitingstarted 2026, after this paper: background citation

Effect of Semaglutide on Embryo Quality in Overweight and Obese Patients Undergoing In Vitro Fertilization. A Randomized Controlled Trial

Ran2026Enrolled62Registered outcomes23Posted comparisons0ConditionsInfertility, ObesityArmsNo pre-treatment, semaglutide
PMID 29703793PMID 33567185PMID 40142784PMID 39696822PMID 38810863PMID 38444070PMID 38339186PMID 37762856PMID 37427372PMID 36635080PMID 36551163PMID 33257906other papers from this trial
Open the trial in the graph
NCT04029532 completednot on this mapstarted 2019, after this paper: background citation

Factors Associated With Obesity in Adult Women: Respiratory Exchange Ratio, Heart Rate Variation and Body Image

TypeobservationalSponsorNational Taiwan University HospitalRan2019 to 2020Enrolled121ConditionsObesityArmsRespiratory exchange ratio, Heart rate variability, Body composition, Eating behavior, Physical activity recall
3 · Its place in the literature

Who cites it

290 citing papers in PubMed, 9 syntheses or guidelines pooled it, 638 citations in OpenAlex.

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  12. Effect of catgut embedding at acupoints versus non-acupoints in abdominal obesity: a randomized clinical trial.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023
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230 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Erica SilvestrisInterdisciplinary Department of Medicine, Section of Obstetrics and Gynecology, University of Bari Aldo Moro, P.za G.Cesare, 11-70124, Bari, Italy. ericasilvestris85@gmail.com.ORCID http://orcid.org/0000-0001-7415-5986
Giovanni de PergolaDepartmentof Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro, P.za G.Cesare, 11-70124, Bari, Italy.
Raffaele RosaniaInterdisciplinary Department of Medicine, Section of Obstetrics and Gynecology, University of Bari Aldo Moro, P.za G.Cesare, 11-70124, Bari, Italy.
Giuseppe LoverroInterdisciplinary Department of Medicine, Section of Obstetrics and Gynecology, University of Bari Aldo Moro, P.za G.Cesare, 11-70124, Bari, Italy.
University of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Both obesity and overweight are increasing worldwide and have detrimental influences on several human body functions including the reproductive health. In particular, obese women undergo perturbations of the 'hypothalamic pituitary ovarian axis', and frequently suffer of menstrual dysfunction leading to anovulation and infertility. Besides the hormone disorders and subfertility that are common in the polycystic ovary syndrome (PCOS), in obesity the adipocytes act as endocrine organ. The adipose tissue indeed, releases a number of bioactive molecules, namely adipokines, that variably interact with multiple molecular pathways of insulin resistance, inflammation, hypertension, cardiovascular risk, coagulation, and oocyte differentiation and maturation. Moreover, endometrial implantation and other reproductive functions are affected in obese women with complications including delayed conceptions, increased miscarriage rate, reduced outcomes in assisted conception treatments.On the contrary, weight loss programs through lifestyle modification in obese women, have been proven to restore menstrual cyclicity and ovulation and improve the likelihood of conception.

Indexed as

FemaleHumansInfertility, FemaleObesityAdipokinesAnovulationInfertilityObesityOocytes

Identifiers

PMID29523133
PMCPMC5845358
OpenAlexW2800554476

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.