Evidence map›Paper›PMID 29643479›Full record

SynthesisScientific reports2018

Use of statins and the risk of dementia and mild cognitive impairment: A systematic review and meta-analysis.

Che-Sheng Chu, Ping-Tao Tseng, Brendon Stubbs, Tien-Yu Chen, Chia-Hung Tang, Dian-Jeng Li, Wei-Cheng Yang, Yen-Wen Chen, Ching-Kuan Wu, Nicola Veronese and 4 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 11 pooled it
24.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 11 syntheses or guidelines pooled it, 194 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Cerebrolysin for vascular dementia.The Cochrane database of systematic reviews · 2019
    Pooled it
  12. Trial
  13. Observational
  14. Article
  15. Article
  16. Article
  17. Observational
  18. Article
  19. Article
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 6 countries.

Che-Sheng ChuDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Ping-Tao TsengDepartment of Psychiatry, Tsyr-Huey Mental Hospital, Kaohsiung Jen-Ai's Home, Kaohsiung, Taiwan.ORCID 0000-0001-5761-7800
Brendon StubbsPhysiotherapy Department, South London and Maudsley NHS Foundation Trust, London, UK.
Tien-Yu ChenDepartment of Psychiatry, Tri-Service General Hospital; School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Chia-Hung TangDepartment of Psychiatry, Tainan Hospital, Ministry of Health and Welfare, Tainan, Taiwan.
Dian-Jeng LiDepartment of Addiction Science, Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan.ORCID 0000-0002-6036-045X
Wei-Cheng YangDepartment of Adult Psychiatry, Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan.
Yen-Wen ChenProspect clinic for otorhinolaryngology & neurology, Kaohsiung, Taiwan.
Ching-Kuan WuCenter for Geriatric and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Nicola VeroneseNational Research Council, Neuroscience Institute, Aging Branch, Padova, Italy.
Andre F CarvalhoDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Brisa S FernandesIMPACT Strategic Research Centre, School of Medicine, and Barwon Health, Deakin University, Geelong, Australia.
Nathan HerrmannNeuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Pao-Yen LinDepartment of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. py1029@adm.cgmh.org.tw.
Kaohsiung Veterans General Hospital · TWCentre for Addiction and Mental Health · CAChang Gung University · TWChest Hospital, Ministry of Health and Welfare · TWKaohsiung Medical University · TWKaohsiung Municipal Kai-Syuan Psychiatric Hospital · TWKing's College London · GBNeuroscience Institute · ITSunnybrook Health Science Centre · CATri-Service General Hospital · TWUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer's disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27

Indexed as

Cognitive DysfunctionDementiaHumansHydroxymethylglutaryl-CoA Reductase InhibitorsRisk AssessmentHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID29643479
PMCPMC5895617
OpenAlexW2796659858

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.